Mendes António M, Albuquerque Inês S, Machado Marta, Pissarra Joana, Meireles Patrícia, Prudêncio Miguel
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
Antimicrob Agents Chemother. 2017 Jan 24;61(2). doi: 10.1128/AAC.02005-16. Print 2017 Feb.
Avermectins are powerful endectocides with an established potential to reduce the incidence of vector-borne diseases. Here, we show that several avermectins inhibit the hepatic stage of Plasmodium infection in vitro Notably, ivermectin potently inhibits liver infection in vivo by impairing parasite development inside hepatocytes. This impairment has a clear impact on the ensuing blood stage parasitemia, reducing disease severity and enhancing host survival. Ivermectin has been proposed as a tool to control malaria transmission because of its effects on the mosquito vector. Our study extends the effect of ivermectin to the early stages of mammalian host infection and supports the inclusion of this multipurpose drug in malaria control strategies.
阿维菌素是强效的体内外寄生虫杀虫剂，具有降低媒介传播疾病发病率的既定潜力。在此，我们表明几种阿维菌素在体外可抑制疟原虫感染的肝脏阶段。值得注意的是，伊维菌素通过损害肝细胞内的寄生虫发育在体内有效抑制肝脏感染。这种损害对随后的血液阶段寄生虫血症有明显影响，降低了疾病严重程度并提高了宿主存活率。由于伊维菌素对蚊媒有作用，它已被提议作为控制疟疾传播的一种工具。我们的研究将伊维菌素的作用扩展到哺乳动物宿主感染的早期阶段，并支持将这种多用途药物纳入疟疾控制策略。
