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小鼠妊娠早期子宫组织的基底膜超微结构及成分定位数据。

Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy.

作者信息

Jones-Paris Celestial R, Paria Sayan, Berg Taloa, Saus Juan, Bhave Gautam, Paria Bibhash C, Hudson Billy G

机构信息

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States; Aspirnaut, Vanderbilt University Medical Center, Nashville, Tennessee, United States.

Aspirnaut, Vanderbilt University Medical Center, Nashville, Tennessee, United States.

出版信息

Data Brief. 2016 Nov 5;9:931-939. doi: 10.1016/j.dib.2016.10.033. eCollection 2016 Dec.

Abstract

Basement membranes (BMs) are specialized extracellular scaffolds that provide architecture and modulate cell behaviors in tissues, such as fat, muscle, endothelium, endometrium, and decidua. Properties of BMs are maintained in homeostasis for most adult tissues. However, BM ultrastructure, composition, and localization are rapidly altered in select uterine tissues that are reprogrammed during pregnancy to enable early maternal-embryo interactions. Here, our data exhibit both static and dynamic BMs that were tracked in mouse uterine tissues during pre-, peri-, and postimplantation periods of pregnancy. The data exhibit spatial-temporal patterns of BM property regulation that coincide with the progression of adapted physiology. Further interpretation and discussion of these data in this article are described in the associated research article titled, "Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming" (C.R. Jones-Paris, S. Paria, T. Berg, J. Saus, G. Bhave, B.C. Paria, B.G. Hudson, 2016) [1].

摘要

基底膜(BMs)是一种特殊的细胞外支架,可为组织(如脂肪、肌肉、内皮、子宫内膜和蜕膜)提供结构并调节细胞行为。对于大多数成年组织而言,基底膜的特性在稳态中得以维持。然而,在妊娠期间会进行重新编程以实现早期母体 - 胚胎相互作用的特定子宫组织中,基底膜的超微结构、组成和定位会迅速改变。在这里,我们的数据展示了在小鼠子宫组织妊娠植入前、植入期和植入后阶段所追踪到的静态和动态基底膜。这些数据展示了基底膜特性调节的时空模式,这与适应性生理过程的进展相一致。本文对这些数据的进一步解读和讨论在相关研究文章《胚胎植入触发子宫重编程过程中基底膜工具包的动态时空表达》(C.R. 琼斯 - 帕里斯、S. 帕里亚、T. 伯格、J. 索斯、G. 巴韦、B.C. 帕里亚、B.G. 哈德森,2016年)[1]中有描述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bed9/5118616/fb724b021dc7/gr1.jpg

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