去甲肾上腺素能对奥沙利铂诱导的痛觉过敏大鼠皮肤冷刺激引起的脊髓过度兴奋的抑制作用：电生理和行为学评估
Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia: electrophysiological and behavioral assessments.
作者信息
Choi Seunghwan, Yamada Akihiro, Kim Woojin, Kim Sun Kwang, Furue Hidemasa
机构信息
Department of Physiology, College of Korean Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, 444-8787, Japan.
出版信息
J Physiol Sci. 2017 May;67(3):431-438. doi: 10.1007/s12576-016-0505-9. Epub 2016 Nov 28.
Abstract
We investigated the spinal action of noradrenaline on cold-elicited hyperexcitation detected in dorsal horn neurons of rats with allodynia induced by an oxaliplatin (6 mg/kg, i.p.) injection. In vivo extracellular recordings from the spinal dorsal horn showed that wide dynamic range neurons responded to cutaneous acetone (10 μl) stimulation in normal rats, and cold-elicited firings in oxaliplatin-administered rats were increased with a longer duration, correlated with behavioral responses. These responses were significantly attenuated by spinal administration (50 μM) of noradrenaline or its agonists, clonidine (α), phenylephrine (α) and isoprenaline (β), in descending order of efficacy. Thus, the inhibitory effect of noradrenaline on spinal oxaliplatin-induced cold hyperexcitation is mediated mainly by activation of α- and/or α-adrenoceptors.
摘要
我们研究了去甲肾上腺素对奥沙利铂（6毫克/千克，腹腔注射）诱导的痛觉过敏大鼠背角神经元中冷诱发的过度兴奋的脊髓作用。脊髓背角的体内细胞外记录显示，正常大鼠的广动力范围神经元对皮肤丙酮（10微升）刺激有反应，奥沙利铂给药大鼠的冷诱发放电增加且持续时间更长，与行为反应相关。脊髓给予（50微摩尔）去甲肾上腺素或其激动剂可乐定（α）、去氧肾上腺素（α）和异丙肾上腺素（β）后，这些反应按效力从高到低显著减弱。因此，去甲肾上腺素对脊髓奥沙利铂诱导的冷过度兴奋的抑制作用主要由α和/或β肾上腺素能受体的激活介导。
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