Beijing Innovation Centre for Intelligent Robots and Systems, Beijing Institute of Technology, Beijing 100081, China.
School of Mechatronical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Biosensors (Basel). 2021 Dec 8;11(12):503. doi: 10.3390/bios11120503.
Neural interfaces typically focus on one or two sites in the motoneuron system simultaneously due to the limitation of the recording technique, which restricts the scope of observation and discovery of this system. Herein, we built a system with various electrodes capable of recording a large spectrum of electrophysiological signals from the cortex, spinal cord, peripheral nerves, and muscles of freely moving animals. The system integrates adjustable microarrays, floating microarrays, and microwires to a commercial connector and cuff electrode on a wireless transmitter. To illustrate the versatility of the system, we investigated its performance for the behavior of rodents during tethered treadmill walking, untethered wheel running, and open field exploration. The results indicate that the system is stable and applicable for multiple behavior conditions and can provide data to support previously inaccessible research of neural injury, rehabilitation, brain-inspired computing, and fundamental neuroscience.
神经接口通常由于记录技术的限制，只能同时关注运动神经元系统中的一个或两个位点，这限制了对该系统的观察和发现的范围。在这里，我们构建了一个系统，该系统具有各种电极，能够从自由移动动物的大脑皮层、脊髓、周围神经和肌肉中记录大量的电生理信号。该系统将可调节的微阵列、浮动微阵列和微丝集成到商业连接器和无线发射器上的袖带电极上。为了说明该系统的多功能性，我们研究了它在拴系跑步机行走、无拴系轮跑和开阔场探索期间啮齿动物行为的性能。结果表明，该系统稳定且适用于多种行为条件，并能够提供数据支持以前无法获得的神经损伤、康复、脑启发计算和基础神经科学研究。
