Liu Jianzhong, Wu Kai, Shen Tao, Liang Yujie, Zou Miancheng, Zhu Yuchao, Li Xinwei, Li Xinyao, Jiao Ning
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences Peking University, Xue Yuan Rd. 38, Beijing, 100191, P. R. China.
State Key Laboratory of Organometallic Chemistry, Chinese Academy of Sciences, Shanghai, 200032, P. R. China.
Chemistry. 2017 Jan 12;23(3):563-567. doi: 10.1002/chem.201605476. Epub 2016 Dec 16.
A novel and efficient Fe-catalyzed direct C-H amination (NH ) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.
报道了一种使用新型氧化还原活性胺化试剂的新颖且高效的铁催化芳烃直接C-H胺化（NH）反应。该反应简单，可在空气中、温和且氧化还原中性的条件下进行。此方法具有广泛的底物范围，可用于生物活性化合物的后期修饰。机理研究表明，该转化过程可能涉及自由基途径。
