白细胞介素-4信使核糖核酸在患有恶病质的胰腺癌患者肝脏中表达下调。
IL-4 mRNA Is Downregulated in the Liver of Pancreatic Cancer Patients Suffering from Cachexia.
作者信息
Prokopchuk Olga, Steinacker Jürgen M, Nitsche Ulrich, Otto Stephanie, Bachmann Jeannine, Schubert Elaine C, Friess Helmut, Martignoni Marc E
机构信息
a Department of Surgery , Klinikum rechts der Isar, Technische Universität München , Munich , Germany.
b Division of Sports and Rehabilitation Medicine, Department of Internal Medicine II , University of Ulm , Ulm , Germany.
出版信息
Nutr Cancer. 2017 Jan;69(1):84-91. doi: 10.1080/01635581.2017.1247885. Epub 2016 Nov 29.
BACKGROUND
Interleukin-4 (IL-4) together with interleukin-13 (IL-13) play an important role in inflammation and wound repair, and are known to be upregulated in human skeletal muscle after strenuous physical exercise. Additionally, these cytokines may act as autocrine growth factors in pancreatic cancer cells. We hypothesize that IL-4, IL-13, and their corresponding receptors are involved in mechanism of cancer cachexia.
METHODS
Tissue samples from human skeletal muscle, white fat, liver, healthy pancreas, and pancreatic ductal adenocarcinoma were analyzed by quantitative real-time polymerase chain reaction for mRNA expression levels of IL-4, IL-13, IL-4 receptor α, and IL-13 receptor α1.
RESULTS
We demonstrate for the first time that liver IL-4 mRNA is downregulated in vivo in patients with pancreatic cancer and cachexia. Additionally, IL-4 mRNA in the liver inversely correlated with musculus psoas thickness.
CONCLUSION
We speculate that suppression of IL-4 is involved in cancer cachexia, although the exact mechanisms have to be further elucidated.
背景
白细胞介素-4（IL-4）与白细胞介素-13（IL-13）在炎症和伤口修复中发挥重要作用，并且已知在剧烈体育锻炼后人体骨骼肌中会上调。此外，这些细胞因子可能在胰腺癌细胞中作为自分泌生长因子起作用。我们推测IL-4、IL-13及其相应受体参与癌症恶病质的机制。
方法
通过定量实时聚合酶链反应分析来自人体骨骼肌、白色脂肪、肝脏、健康胰腺和胰腺导管腺癌的组织样本中IL-4、IL-13、IL-4受体α和IL-13受体α1的mRNA表达水平。
结果
我们首次证明，胰腺癌和恶病质患者体内肝脏IL-4 mRNA表达下调。此外，肝脏中的IL-4 mRNA与腰大肌厚度呈负相关。
结论
我们推测IL-4的抑制与癌症恶病质有关，尽管确切机制有待进一步阐明。
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