Gasparova Iveta, Kubatka Peter, Opatrilova Radka, Caprnda Martin, Filipova Slavomira, Rodrigo Luis, Malan Leone, Mozos Ioana, Rabajdova Miroslava, Nosal Vladimir, Kobyliak Nazarii, Valentova Vanda, Petrovic Daniel, Adamek Mariusz, Kruzliak Peter
Institute of Biology, Genetics and Medical Genetics, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovak Republic, Slovakia.
Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovak Republic, Slovakia.
Naunyn Schmiedebergs Arch Pharmacol. 2017 Jan;390(1):1-14. doi: 10.1007/s00210-016-1320-9. Epub 2016 Nov 29.
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.
心房颤动（AF）是最常见的持续性心律失常，与显著的发病率和死亡率相关。尽管电生理重塑被认为是一个重要的起始步骤，但AF发病机制的根本原因仍知之甚少。越来越多的证据表明氧化应激参与了AF的发病机制。许多已知的氧化应激触发因素，如年龄、糖尿病、吸烟和炎症，都与心律失常风险增加有关。大量临床前研究和临床试验报告了使用维生素C和E、多不饱和脂肪酸、他汀类药物或一氧化氮供体进行抗氧化治疗在预防AF方面的重要性。我们这项工作的目的是对AF抗氧化治疗的机遇、挑战和益处进行当前的概述和分析。
