Yi Wenwen, Yang Yuanyuan, Hashemi Parastoo, Cheng Mark Ming-Cheng
Department of Electrical and Computer Engineering, Wayne State University, 5050 Anthony Wayne Drive, Detroit, MI, 48202, USA.
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, MI, 48202, USA.
Biomed Microdevices. 2016 Dec;18(6):112. doi: 10.1007/s10544-016-0136-1.
In this paper, we have fabricated 3D carbon nanofiber microelectrode arrays (MEAs) with highly reproducible and rich chemical surface areas for fast scan cyclic voltammetry (FSCV). Carbon nanofibers are created from negative photoresist by a new process called dual O plasma-assisted pyrolysis. The proposed approach significantly improves film adhesion and increases surface reactivity. We showcase our sensor's compatibility with FSCV analysis by demonstrating highly sensitive and stable FSCV dopamine measurements on a prototype 4-channel array. We envision with proper surface fuctionalization the 3D carbon nanofiber MEA enable sensitive and reliable detection of multiple neurotransmitters simultaneously.
在本文中，我们制备了具有高度可重复性和丰富化学表面积的三维碳纳米纤维微电极阵列（MEA），用于快速扫描循环伏安法（FSCV）。碳纳米纤维是通过一种名为双O等离子体辅助热解的新工艺由负性光刻胶制成的。所提出的方法显著提高了薄膜附着力并增加了表面反应性。我们通过在原型4通道阵列上展示高灵敏度和稳定的FSCV多巴胺测量，展示了我们的传感器与FSCV分析的兼容性。我们设想，通过适当的表面功能化，三维碳纳米纤维MEA能够同时灵敏可靠地检测多种神经递质。
