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围术期心脏风险分层的临床指标和生物标志物:更新。

Clinical indices and biomarkers for perioperative cardiac risk stratification: an update.

机构信息

Department of Anesthesiology and Intensive Care, School of Medicine, University of Niš, Niš, Serbia -

Center for Anesthesiology and Reanimatology, Clinical Center of Niš, Niš, Serbia -

出版信息

Minerva Anestesiol. 2017 Apr;83(4):392-401. doi: 10.23736/S0375-9393.16.11545-7. Epub 2016 Nov 30.

Abstract

European Society of Cardiology (ESC)/ European Society of Anesthesiology (ESA) highlighted that anesthesiologist has a leading role in perioperative cardiovascular assessment and management in the year of 2014. During cardiovascular assessment one can rely on cooperation of multidisciplinary specialists like: other anesthesiologists, cardiologists and surgeons. For the purpose of precise systematization and decision making the Lee Score or NSQUIP database can be used besides the traditionally used ASA Score. Additional help is provided with specific palette of cardiac biomarkers like: cardiac troponins T, cardiac troponins I, C-reactive protein, N-terminal pro-brain natriuretic peptide, brain natriuretic peptide, etc. Biomarkers are considered to represent a foundation of evidence based medicine and they help anesthesiologists in the decision-making process. They increase the chance to achieve the best clinical outcome for each patient. An ideal biomarker does not exist and therefore new research are currently being conducted with the aim to find and declare more specific biomarkers like heart-type fatty acid-binding protein, micro RNA, PAMP and high sensitivity troponins T.

摘要

欧洲心脏病学会(ESC)/欧洲麻醉学会(ESA)强调,麻醉师在 2014 年的围手术期心血管评估和管理中发挥着主导作用。在心血管评估过程中,可以依靠多学科专家的合作,如其他麻醉师、心脏病专家和外科医生。为了进行精确的系统化和决策,可以使用 Lee 评分或 NSQUIP 数据库,除了传统使用的 ASA 评分。还可以使用特定的心脏生物标志物谱,如心脏肌钙蛋白 T、心脏肌钙蛋白 I、C 反应蛋白、N 端脑利钠肽前体、脑利钠肽等,提供额外的帮助。生物标志物被认为是循证医学的基础,它们有助于麻醉师在决策过程中做出决策。它们增加了为每位患者获得最佳临床结果的机会。目前正在进行新的研究,以寻找和宣布更具特异性的生物标志物,如心脏型脂肪酸结合蛋白、microRNA、PAMP 和高敏肌钙蛋白 T,理想的生物标志物并不存在。

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