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[核苷酸对大赤鱿视神经节烟碱型乙酰胆碱受体结合N-甲基野靛碱和二甲基筒箭毒碱的影响]

[Effect of nucleotides on N-methylcytisine and dimethyltubocurarine binding by the nicotinic acetylcholine receptors of the optic ganglia in the squid B. magister].

作者信息

Pliashkevich Iu G, Demushkin V P

出版信息

Biull Eksp Biol Med. 1989 Jun;107(6):706-9.

PMID:2790167
Abstract

The effect of nucleosides mono-, di-, and triphosphates on binding of 3H-N-methylcytisine and 14C-tubocurarine to nAChR from squid optical ganglia were investigated. It was found, that ATP and GTP potentiate the specific binding of 3H-N-methylcytisine and inhibit the one of 14C-tubocurarine. While conducting the photoaffinity modification of nACHR by 3H-azidomethylcytisine in the presence of ATP the increase of specific incorporation of label was observed in comparison with control. Molecular weight of labeled receptor complex and subunit, carrying the binding site was the same as the original.

摘要

研究了单磷酸、二磷酸和三磷酸核苷对3H-N-甲基野靛碱和14C-筒箭毒碱与鱿鱼视神经节烟碱型乙酰胆碱受体（nAChR）结合的影响。发现ATP和GTP增强3H-N-甲基野靛碱的特异性结合，并抑制14C-筒箭毒碱的特异性结合。在ATP存在下，用3H-叠氮甲基野靛碱对nACHR进行光亲和修饰时，与对照相比，观察到标记物特异性掺入增加。标记的受体复合物和携带结合位点的亚基的分子量与原始的相同。

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