Sergeev P V, Kul'berg A Ia, Shimanovskiĭ N L, Napolov Iu K, Ukhanov S V
Biull Eksp Biol Med. 1989 Jun;107(6):716-8.
The purpose of the work was to demonstrate the effect of radiographic contrast media (RCM) 50% bilignost, 76% triombrast, 80% iodamide-380 on the complement system in rats. It has been found that RCM cause alternative complement activation during incubation with the whole blood or serum in vivo and in vitro. The RCM effect value depends on the drug dose and increase in the order: triombrast iodamide bilignost. Different sensitivity of animals to the effect of RCM on the complement system has been shown.
这项工作的目的是证明50%必利显影、76%碘多啥、80%碘酰胺-380等放射造影剂（RCM）对大鼠补体系统的影响。研究发现，放射造影剂在体内和体外与全血或血清孵育期间会引起替代补体激活。放射造影剂的作用效果取决于药物剂量，且按以下顺序增加：碘多啥、碘酰胺、必利显影。已表明动物对放射造影剂对补体系统作用的敏感性不同。
