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多发性复发性侵袭性成釉细胞瘤:一项手术挑战。

Multi-recurrent invasive ameloblastoma: A surgical challenge.

作者信息

Faras Fatemah, Abo-Alhassan Fawaz, Israël Yona, Hersant Barbara, Meningaud Jean-Paul

机构信息

Department of Plastic and Maxillo-Facial Surgery, Henri Mondor Hospital, Créteil 94010, France.

Department of Plastic and Maxillo-Facial Surgery, Henri Mondor Hospital, Créteil 94010, France.

出版信息

Int J Surg Case Rep. 2017;30:43-45. doi: 10.1016/j.ijscr.2016.11.039. Epub 2016 Nov 21.

Abstract

INTRODUCTION

Ameloblastomas are rare head and neck tumors, and yet the most common odontogenic neoplasms. They account for 1% and 11% of all head and neck and odontogenic tumors respectively. Embryologically, they originate from remnants of odontogenic epithelium. Their aggressive, destructive nature, as well as their anticipated high rate of recurrence, even after en bloc resection, poses a surgical predicament.

PRESENTATION

We present a case of a 56 year-old Asian female with a multi-recurrent invasive ameloblastoma. Initially, the lesion was mandibular in location for which she underwent a mandiblectomy. Later on, she presented with a maxillary ameloblastoma with invasion of both the anterior wall of the maxillary sinus and the floor of the orbit. The patient was operated twice and histopathology confirmed a cystic type recurrent ameloblastoma. A year later, she came with recurrent maxillary ameloblastoma and a maxillectomy was done. However, histopathology revealed a follicular ameloblastoma. Three years later, she presented with a retro-orbital ameloblastoma with infiltration to the temporal muscles. The patient was operated and the histopathologic examination revealed a partially cystic lesion with no malignant transformation.

CONCLUSION

This case discusses available treatment options and emphasizes on the importance of long-term patient follow-up due to the biological behavior of ameloblastoma.

摘要

引言

成釉细胞瘤是罕见的头颈部肿瘤,但却是最常见的牙源性肿瘤。它们分别占所有头颈部肿瘤和牙源性肿瘤的1%和11%。从胚胎学角度来看,它们起源于牙源性上皮的残余物。其侵袭性、破坏性本质,以及即便进行整块切除后仍预期的高复发率,构成了一种手术困境。

病例介绍

我们报告一例56岁亚洲女性复发性侵袭性成釉细胞瘤病例。最初,病变位于下颌骨,为此她接受了下颌骨切除术。后来,她又出现上颌成釉细胞瘤,侵犯上颌窦前壁和眶底。该患者接受了两次手术,组织病理学证实为囊性复发性成釉细胞瘤。一年后,她因复发性上颌成釉细胞瘤前来就诊,接受了上颌骨切除术。然而,组织病理学显示为滤泡型成釉细胞瘤。三年后,她出现眶后成釉细胞瘤并浸润至颞肌。该患者接受了手术,组织病理学检查显示为部分囊性病变,无恶变。

结论

本病例讨论了可用的治疗选择,并强调了由于成釉细胞瘤的生物学行为,对患者进行长期随访的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a116/5133465/7ed90cbb79c7/gr1.jpg

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