Shimura Eiji, Hama Takanori, Suda Toshihito, Ikegami Masahiro, Urashima Mitsuyoshi, Kojima Hiromi
Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan.
Oncology. 2017;92(2):87-93. doi: 10.1159/000452420. Epub 2016 Dec 1.
Few studies have addressed how human papilloma virus (HPV) infection in oropharyngeal squamous cell carcinoma (OPSCC) affects the outcome of surgical therapy; furthermore, the relationship between the presence of HPV DNA and neck lymph node (LN) metastasis has not been well established.
A total of 65 patients who underwent surgery as a first-line therapy for OPSCC were enrolled in this study. In HPV-positive patients, the presence of HPV DNA in metastatic neck LN lesions was evaluated.
The HPV-positive patients had significantly better overall survival than the HPV-negative patients (log-rank test, p = 0.04), whereas HPV infection status did not significantly affect disease-free survival (log-rank test, p = 0.65). In all of the HPV-positive OPSCC patients who developed cervical LN metastasis, the same HPV DNA type was found in both the primary tumour and the metastases.
The present results suggest that HPV infection is a determining factor for good prognosis in patients undergoing first-line surgical therapy for OPSCC.
很少有研究探讨口咽鳞状细胞癌（OPSCC）中的人乳头瘤病毒（HPV）感染如何影响手术治疗的结果；此外，HPV DNA的存在与颈部淋巴结（LN）转移之间的关系尚未完全明确。
本研究共纳入65例接受手术作为OPSCC一线治疗的患者。在HPV阳性患者中，评估转移性颈部LN病变中HPV DNA的存在情况。
HPV阳性患者的总生存期显著优于HPV阴性患者（对数秩检验，p = 0.04），而HPV感染状态对无病生存期没有显著影响（对数秩检验，p = 0.65）。在所有发生颈部LN转移的HPV阳性OPSCC患者中，原发肿瘤和转移灶中均发现相同的HPV DNA类型。
目前的结果表明，HPV感染是接受OPSCC一线手术治疗患者预后良好的决定性因素。
