hERG 通道：从抗靶标到癌症治疗的新靶标。
hERG Channels: From Antitargets to Novel Targets for Cancer Therapy.
机构信息
Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.
出版信息
Clin Cancer Res. 2017 Jan 1;23(1):3-5. doi: 10.1158/1078-0432.CCR-16-2322. Epub 2016 Nov 30.
In this issue of Clinical Cancer Research, evidence is provided on how to avoid cardiotoxicity when targeting hERG K channel for cancer therapy. hERG regulates different aspects of neoplastic progression. Although its blockade has effective anticancer effects in experimental models, it may lead to fatal arrhythmias in humans. Clin Cancer Res; 23(1); 3-5. ©2016 AACRSee related article by Pointer et al., p. 73.
在本期《临床癌症研究》中，提供了如何在针对 hERG K 通道进行癌症治疗时避免心脏毒性的证据。hERG 调节肿瘤进展的不同方面。尽管其阻断在实验模型中具有有效的抗癌作用，但它可能导致人类致命的心律失常。临床癌症研究; 23(1); 3-5。©2016AACR 参见 Pointer 等人的相关文章，第 73 页。
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