甲状腺功能亢进大鼠离体心脏的电生理异常与再灌注心律失常增强
Electrophysiological abnormalities and enhanced reperfusion arrhythmias in the isolated hearts of hyperthyroid rats.
作者信息
Miyazawa K, Hashimoto H, Uematsu T, Nakashima M
机构信息
Department of Pharmacology, Hamamatsu University School of Medicine, Shizuoka, Japan.
出版信息
Br J Pharmacol. 1989 Aug;97(4):1093-100. doi: 10.1111/j.1476-5381.1989.tb12566.x.
Abstract
- The influence of hyperthyroidism on electrophysiological characteristics and on reperfusion arrhythmias was examined in rat hearts. 2. Electrophysiological studies were performed with glass microelectrodes, and the experiments on reperfusion arrhythmias were done in isolated perfused hearts. 3. Ventricular muscle from hyperthyroid rats was more prone than that from euthyroid rats to develop triggered activity under conditions believed to cause myoplasmic Ca2+ overload. 4. The severity of reperfusion arrhythmias was significantly enhanced in hyperthyroid preparations as compared with euthyroid ones. 5. The enhanced reperfusion arrhythmias in hyperthyroid rats were significantly reduced by propranolol (3 x 10(-7) M), lignocaine (1 x 10(-5) M) and verapamil (3 x 10(-8) M), but not by nadolol (3 x 10(-7) M) or prazosin (3 x 10(-7) M). 6. These results suggest that increased heart rate due to hyperthyroidism and responses mediated via either alpha- or beta-adrenoceptors were not dominant causes of enhanced reperfusion arrhythmias in hyperthyroid hearts. 7. The increased tendency to develop triggered activity which was observed in the electrophysiological study, may be one possible explanation of enhanced reperfusion arrhythmias in hyperthyroid hearts.
摘要
- 在大鼠心脏中研究了甲状腺功能亢进对电生理特性和再灌注心律失常的影响。2. 使用玻璃微电极进行电生理研究，再灌注心律失常实验在离体灌注心脏中进行。3. 在被认为会导致肌浆Ca2+过载的条件下，甲状腺功能亢进大鼠的心室肌比甲状腺功能正常大鼠的心室肌更容易产生触发活动。4. 与甲状腺功能正常的制剂相比，甲状腺功能亢进制剂中再灌注心律失常的严重程度显著增强。5. 普萘洛尔（3×10(-7)M）、利多卡因（1×10(-5)M）和维拉帕米（3×10(-8)M）可显著减轻甲状腺功能亢进大鼠增强的再灌注心律失常，但纳多洛尔（3×10(-7)M）或哌唑嗪（3×10(-7)M）则不能。6. 这些结果表明，甲状腺功能亢进导致的心率增加以及通过α或β肾上腺素能受体介导的反应不是甲状腺功能亢进心脏中再灌注心律失常增强的主要原因。7. 在电生理研究中观察到的产生触发活动的倾向增加，可能是甲状腺功能亢进心脏中再灌注心律失常增强的一种可能解释。
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