Cox H M, Ferrar J A, Cuthbert A W
Department of Pharmacology, University of Cambridge.
Br J Pharmacol. 1989 Aug;97(4):996-8. doi: 10.1111/j.1476-5381.1989.tb12553.x.
Both alpha- and beta-calcitonin gene-related peptide (CGRP) exhibit concentration-dependent dual actions upon rat colonic epithelia. At low concentrations (i.e. 0.03-10 nM) both CGRPs produce antisecretory effects that are abolished by pretreating tissues with tetrodotoxin (TTX). At higher concentrations (30-200 nM) secretory responses predominate and these effects are not abolished by TTX. It is suggested that the mediator of the antisecretory actions of CGRPs is somatostatin.
α-降钙素基因相关肽（CGRP）和β-降钙素基因相关肽对大鼠结肠上皮均表现出浓度依赖性的双重作用。在低浓度（即0.03 - 10 nM）时，两种CGRP均产生抗分泌作用，用河豚毒素（TTX）预处理组织可消除该作用。在较高浓度（30 - 200 nM）时，分泌反应占主导，且这些作用不能被TTX消除。有人提出，CGRP抗分泌作用的介质是生长抑素。
