评估孕期补充叶酸在改变口腔腭裂患儿亚甲基四氢叶酸还原酶（C677T和A1298C）基因多态性影响方面的作用。
Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children.
作者信息
Ebadifar Asghar, Ameli Nazila, KhorramKhorshid Hamid Reza, Kamali Koorosh, Zeinabadi Mehdi Salehi
机构信息
Dentofacial Deformities Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Orthodontic, Dental School, Semnan University of Medical Sciences, Semnan, Iran.
出版信息
J Res Med Sci. 2016 Aug 1;21:59. doi: 10.4103/1735-1995.187307. eCollection 2016.
BACKGROUND
We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase ( C677T and A1298C) gene polymorphisms in Iranian children with oral clefts.
MATERIALS AND METHODS
Forty-seven newborn infants with orofacial cleft and their mothers were selected randomly. Mothers were matched regarding dietary folate intake. The genotyping on venous blood was carried out. Consistency between maternal and child genotypes was analyzed.
RESULTS
Genotype consistency was not statistically significant in both C677T and A1298C gene variants ( > 0.05).
CONCLUSION
Maternal folic acid consumption may not have any significant effect on modifying C677T and A1298C polymorphisms in children.
背景
我们研究了孕期补充叶酸在改变伊朗唇腭裂儿童亚甲基四氢叶酸还原酶（C677T和A1298C）基因多态性影响方面的作用。
材料与方法
随机选取47例患有口面部裂隙的新生儿及其母亲。根据膳食叶酸摄入量对母亲进行匹配。对静脉血进行基因分型。分析母婴基因型之间的一致性。
结果
C677T和A1298C基因变异的基因型一致性均无统计学意义（>0.05）。
结论
孕期补充叶酸可能对改变儿童C677T和A1298C基因多态性无显著影响。
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