Escribano-Serrano José, Mancera-Romero José, Santos-Sánchez Vanessa, Payá-Giner Carolina, Méndez-Esteban Mª Isabel, García-Bonilla Antonio, Márquez-Ferrando Manuela, Hormigo-Pozo Antonio, Michán-Doña Alfredo
Unidad de Gestión Clínica de San Roque. Área de Gestión Sanitaria Campo de Gibraltar. Cádiz. España.
Unidad de Gestión Clínica Ciudad Jardín. Distrito de Atención Primaria Málaga-Guadalhorce. Málaga. España.
Rev Esp Salud Publica. 2016 Dec 2;90:e1-e12.
Hypothyroidism is the most common condition linked to a hormone deficiency, nevertheless data on its prevalence are scarce in Spain. For that reason, we have estimated its prevalence through the registration of patients who had used thyroid hormones in Andalusia (South Spain).
Data of patients who had withdrawn levothyroxine under the public system during 2014 from the base of the Andalusian Health Service were considered. Prevalence were calculated with confidence intervals of 95% for each management area, stratified by sex and age groups, and differences between them were evaluated.
321,368 people (98% older than 18 years and 83% female) were identified as levothyroxine users and a prevalence of hypothyroidism of 3.95% (95%CI:3.94-3.96) was estimated for the general population. The condition was more common in females, in the older 18 years 7.81% (95%CI:7.80 to 7.82) compared to males 1.75% (95%CI:1.73-1.77) with a ratio of 4.5-fold. It increases in the population of women older than 45 years, 10.32% (95%CI:10.30-0.32) and in the over 60 years 11.37% (95%CI: 11.35-11.40). The prevalence in adult women in the western provinces is 7.38% (95%CI:7.36-7.40), in the eastern provinces 8.59% (95%CI:8.57-8.62) and in coastal areas 6.70% (95%CI: 6.68-6.72) compared to the mountainous ones, which is 8.91% (95%CI:8.88-8.94).
The results denote a high prevalence of hypothyroidism in the adult population of Andalusia compared to the nearby countries, with a clear increased associated with females and age. Furthermore, the prevalence of the illness presents also a geographically-related variability.
甲状腺功能减退是与激素缺乏相关的最常见病症，然而在西班牙，关于其患病率的数据却很稀少。因此，我们通过登记安达卢西亚（西班牙南部）使用甲状腺激素的患者来估算其患病率。
研究考虑了安达卢西亚卫生服务数据库中2014年期间在公共系统停用左甲状腺素的患者数据。计算每个管理区域按性别和年龄组分层的患病率及其95%置信区间，并评估它们之间的差异。
共识别出321,368名左甲状腺素使用者（98%年龄大于18岁，83%为女性），估计普通人群甲状腺功能减退患病率为3.95%（95%置信区间：3.94 - 3.96）。该病症在女性中更为常见，18岁及以上女性患病率为7.81%（95%置信区间：7.80至7.82），男性为1.75%（95%置信区间：1.73 - 1.77），两者比例为4.5倍。在45岁以上女性人群中患病率上升至10.32%（95%置信区间：10.30 - 10.32），60岁以上人群中为11.37%（95%置信区间：11.35 - 11.40）。与山区相比，西部省份成年女性患病率为7.38%（95%置信区间：7.36 - 7.40），东部省份为8.59%（95%置信区间：8.57 - 8.62），沿海地区为6.70%（95%置信区间：6.68 - 6.72），山区为8.91%（95%置信区间：8.88 - 8.94）。
结果表明，与周边国家相比，安达卢西亚成年人群中甲状腺功能减退患病率较高，且明显与女性和年龄相关。此外，该疾病的患病率在地理上也存在差异。
