Ruiz-Villaverde Ricardo, Cebolla-Verdugo Marta, Llamas-Segura Carlos, Ezomo-Gervilla Pedro José, Molina-Espinosa Jose, Ruiz-Carrascosa Jose Carlos
Department of Dermatology, Hospital Universitario San Cecilio, 18016 Granada, Spain.
Instituto Biosanitario de Granada (ibs.GRANADA), 18014 Granada, Spain.
Diseases. 2025 Jul 25;13(8):237. doi: 10.3390/diseases13080237.
: Psoriasis is a chronic inflammatory skin disease linked to systemic comorbidities, including metabolic, cardiovascular, and autoimmune disorders. Thyroid dysfunction, particularly hypothyroidism, has been observed in patients with moderate-to-severe psoriasis, suggesting possible shared inflammatory pathways. : This study aims to explore the relationship between psoriasis and thyroid dysfunction in adults with moderate-to-severe psoriasis undergoing biologic therapy to determine whether psoriasis predisposes individuals to thyroid disorders and to identify demographic or clinical factors influencing this association. : A cross-sectional study included adult patients with moderate-to-severe psoriasis receiving biologic therapy, recruited from the Psoriasis Unit at the Dermatology Department of Hospital Universitario San Cecilio in Granada, Spain, from 2017 to 2023. Patients with mild psoriasis or those treated with conventional systemic therapies were excluded. The data collected included demographics and clinical characteristics, such as age, sex, BMI (body mass index), and psoriasis severity (psoriasis severity was evaluated using the Psoriasis Area Severity Index (PASI), body surface area (BSA) involvement, Investigator's Global Assessment (IGA), pruritus severity using the Numerical Rating Scale (NRS), and impact on quality of life through the Dermatology Life Quality Index (DLQI)). Thyroid dysfunction, including hypothyroidism and subclinical hypothyroidism, was assessed based on records from the Endocrinology Department. : Thyroid dysfunction was found in 4.2% of patients, all classified as hypothyroidism, primarily subclinical. The affected patients were generally older, with a mean age of 57.4 years. No significant differences in psoriasis severity (PASI, BSA) or treatment response were observed between patients with and without thyroid dysfunction. : Our findings suggest hypothyroidism is the main thyroid dysfunction in psoriatic patients, independent of psoriasis severity. The lack of impact on psoriasis severity suggests hypothyroidism may be an independent comorbidity, warranting further research into shared inflammatory mechanisms.
银屑病是一种慢性炎症性皮肤病，与全身性合并症相关，包括代谢、心血管和自身免疫性疾病。在中度至重度银屑病患者中观察到甲状腺功能障碍，尤其是甲状腺功能减退，提示可能存在共同的炎症途径。：本研究旨在探讨接受生物治疗的中度至重度银屑病成人患者中银屑病与甲状腺功能障碍之间的关系，以确定银屑病是否使个体易患甲状腺疾病，并确定影响这种关联的人口统计学或临床因素。：一项横断面研究纳入了接受生物治疗的中度至重度银屑病成年患者，这些患者于2017年至2023年从西班牙格拉纳达圣塞西利奥大学医院皮肤科银屑病单元招募。排除轻度银屑病患者或接受传统全身治疗的患者。收集的数据包括人口统计学和临床特征，如年龄、性别、体重指数（BMI）和银屑病严重程度（银屑病严重程度采用银屑病面积和严重程度指数（PASI）、体表面积（BSA）受累情况、研究者整体评估（IGA）、使用数字评分量表（NRS）评估的瘙痒严重程度以及通过皮肤病生活质量指数（DLQI）评估的对生活质量的影响）。根据内分泌科记录评估甲状腺功能障碍，包括甲状腺功能减退和亚临床甲状腺功能减退。：4.2%的患者存在甲状腺功能障碍，均被归类为甲状腺功能减退，主要是亚临床的。受影响患者一般年龄较大，平均年龄为57.4岁。有和没有甲状腺功能障碍的患者在银屑病严重程度（PASI、BSA）或治疗反应方面未观察到显著差异。：我们的研究结果表明，甲状腺功能减退是银屑病患者的主要甲状腺功能障碍，与银屑病严重程度无关。对银屑病严重程度缺乏影响表明甲状腺功能减退可能是一种独立的合并症，值得进一步研究共同的炎症机制。
