Landthaler M, Braun-Falco O, Leitl A, Konz B, Hölzel D
Dermatologische Klinik, Ludwig-Maximilians-Universität, München, FRG.
Cancer. 1989 Oct 15;64(8):1612-6. doi: 10.1002/1097-0142(19891015)64:8<1612::aid-cncr2820640810>3.0.co;2-7.
The five-year disease-free rate (5-y-DFR) and five-year survival rate (5-y-SR) of 319 melanoma patients with a narrow excisional biopsy in local anesthesia as the first procedure followed by delayed wide excision, were compared with 5-y-DFR and 5-y-SR of 635 primary radically treated patients. Five-y-DFR and 5-y-SR did not differ in either group of patients. Furthermore, the time interval (less than or equal to 21 days versus greater than 21 days) between excisional biopsy and delayed wide excision had no influence on the outcome of the patients. Based on the results of the study and the literature, excisional biopsy of malignant melanoma followed by delayed wide excision is a safe procedure.
319例以局部麻醉下窄切活检作为首个步骤随后进行延迟广泛切除的黑色素瘤患者的五年无病生存率（5 - y - DFR）和五年生存率（5 - y - SR），与635例接受根治性治疗的原发性患者的5 - y - DFR和5 - y - SR进行了比较。两组患者的5 - y - DFR和5 - y - SR均无差异。此外，切取活检与延迟广泛切除之间的时间间隔（小于或等于21天与大于21天）对患者的预后没有影响。基于该研究结果及文献，恶性黑色素瘤切取活检后进行延迟广泛切除是一种安全的手术。
