Hartley A L, Birch J M, Kelsey A M, Marsden H B, Harris M, Teare M D
Department of Epidemiology and Social Oncology, Christie Hospital, Manchester, England.
Cancer Genet Cytogenet. 1989 Oct 15;42(2):221-6. doi: 10.1016/0165-4608(89)90090-3.
The occurrence of six cases of germ cell tumors, five testicular and one ovarian, in relatives of children with bone or soft tissue sarcomas is described. It is proposed that germ cell tumors may be an uncommon manifestation of the genetic predisposition to cancer that exists in the Li-Fraumeni cancer family syndrome.
本文描述了骨肉瘤或软组织肉瘤患儿亲属中出现6例生殖细胞肿瘤的情况，其中5例为睾丸生殖细胞肿瘤，1例为卵巢生殖细胞肿瘤。有人提出，生殖细胞肿瘤可能是李-弗劳梅尼癌症家族综合征中存在的癌症遗传易感性的一种罕见表现。
