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脑出血和脑室内出血的医学与外科进展

Medical and Surgical Advances in Intracerebral Hemorrhage and Intraventricular Hemorrhage.

作者信息

Ziai Wendy, Carhuapoma J Ricardo, Nyquist Paul, Hanley Daniel F

机构信息

Department of Anesthesiology and Critical Care Medicine, Neurology and Neurosurgery, Johns Hopkins University, Baltimore, Maryland.

Department of Anesthesiology and Critical Care Medicine, Neurology, Neurosurgery, and General Internal Medicine, Johns Hopkins University, Baltimore, Maryland.

出版信息

Semin Neurol. 2016 Dec;36(6):531-541. doi: 10.1055/s-0036-1592190. Epub 2016 Dec 1.

Abstract

In recent decades, the medical and surgical treatment of intracerebral hemorrhage (ICH) have become the focus of a number of scientific investigations. This effort has been led by an international group of neurologists and neurosurgeons with the goal of studying functional recovery and developing new medical and surgical treatments to facilitate improved clinical outcomes. Currently, two of the most pressing ICH investigational goals are (1) early blood pressure control, and (2) safe hematoma volume reduction. Answering these questions would support decision-making, level-of-care choices, and the global research strategy of developing biologically informed treatments. The authors review the contemporary medical management and the conventional and minimally invasive surgical approaches to spontaneous ICH, as well as discuss the scope of the problem, recent clinical trials, management issues, and relevant questions for future research. They propose the hypothesis that strategies using minimally invasive techniques, including clot aspiration with stereotactic guidance, may give better results with improved clinical outcomes compared with standard open surgical approaches. They also discuss the level of evidence for the variously known approaches.

摘要

近几十年来,脑出血(ICH)的药物和手术治疗已成为众多科学研究的焦点。这项工作由国际神经科医生和神经外科医生团队牵头,旨在研究功能恢复情况,并开发新的药物和手术治疗方法以改善临床疗效。目前,脑出血研究中最紧迫的两个目标是:(1)早期血压控制;(2)安全减少血肿体积。回答这些问题将有助于支持决策制定、护理级别选择以及制定基于生物学知识的治疗方法的全球研究策略。作者回顾了自发性脑出血的当代药物治疗以及传统和微创外科手术方法,还讨论了问题的范围、近期临床试验、管理问题以及未来研究的相关问题。他们提出了一个假设,即与标准开放手术方法相比,采用微创技术的策略,包括立体定向引导下的血块抽吸,可能会取得更好的效果并改善临床疗效。他们还讨论了各种已知方法的证据水平。

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