Hofer Matthias D, Liu Joceline S, Morey Allen F
Department of Urology, University of Texas Southwestern, Dallas, TX, USA.
Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Urol Clin North Am. 2017 Feb;44(1):87-92. doi: 10.1016/j.ucl.2016.08.005.
Radiation therapy may result in urethral strictures from vascular damage. Most radiation-induced urethral strictures occur in the bulbomembranous junction, and urinary incontinence may result as a consequence of treatment. Radiation therapy may compromise reconstruction due to poor tissue healing and radionecrosis. Excision and primary anastomosis is the preferred urethroplasty technique for radiation-induced urethral stricture. Principles of posterior urethroplasty for trauma may be applied to the treatment of radiation-induced urethral strictures. Chronic management with suprapubic tube is an option based on patient comorbidities and preference.
放射治疗可能因血管损伤导致尿道狭窄。大多数放射性尿道狭窄发生在球膜部交界处，治疗可能会导致尿失禁。由于组织愈合不良和放射性坏死，放射治疗可能会影响重建。切除并一期吻合是放射性尿道狭窄首选的尿道成形术技术。创伤性后尿道成形术的原则可应用于放射性尿道狭窄的治疗。根据患者的合并症和偏好，耻骨上造瘘管的长期管理也是一种选择。
