Wang Michael T M, Ganesalingam Kalaivarny, Loh Chee Seang, Alberquerque Trisha, Al-Kanani Suhaila, Misra Stuti L, Craig Jennifer P
Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.
Department of Ophthalmology and School of Optometry and Vision Science, New Zealand National Eye Centre, The University of Auckland, New Zealand.
Cont Lens Anterior Eye. 2017 Feb;40(1):53-58. doi: 10.1016/j.clae.2016.11.002. Epub 2016 Nov 28.
To assess the effects of two weeks of regular phospholipid liposomal spray application on lipid layer grade, tear film stability, subjective comfort, visual acuity, and lipid deposition in silicone hydrogel contact lens wearers.
Thirty-one existing contact lens wearers were enrolled and fitted with two week planned replacement silicone hydrogel contact lenses (Acuvue Oasys) in a prospective, randomized, paired-eye, investigator-masked trial. A phospholipid liposomal spray (Tears Again) was applied to one eye (randomized) four times daily for two weeks. LogMAR high contrast visual acuity (VA), low contrast glare acuity (LCGA), non-invasive tear film break-up time (NIBUT), and lipid layer grade (LLG) were measured at baseline and day 14, in both treated and control eyes. Subjective comfort relative to baseline, and spectrofluorophotometric assessment of contact lens surface lipid deposition were also assessed on day 14.
All measurements did not differ at baseline between treated and control eyes. Lipid layer thickness and tear film stability were increased on day 14 in treated eyes (all p<0.05), but not in control eyes (all p>0.05). A greater proportion of participants reported improved comfort in the treated eye relative to the control eye (p=0.002). There were no significant differences in visual acuity or in contact lens surface lipid deposition, between treated and control eyes, on day 14 (all p>0.05).
The phospholipid liposomal spray increased tear film stability, lipid layer thickness and subjective comfort in silicone hydrogel contact lens wearers, without adversely affecting visual acuity or contact lens surface lipid deposition.
评估连续两周定期应用磷脂脂质体喷雾剂对硅水凝胶隐形眼镜佩戴者的脂质层等级、泪膜稳定性、主观舒适度、视力和脂质沉积的影响。
在一项前瞻性、随机、双眼配对、研究者设盲的试验中，招募了31名现有的隐形眼镜佩戴者，并为他们佩戴计划每两周更换一次的硅水凝胶隐形眼镜（安视优欧舒适）。将一种磷脂脂质体喷雾剂（再润眼）随机应用于一只眼睛，每天4次，持续两周。在基线期和第14天，分别测量治疗眼和对照眼的logMAR高对比度视力（VA）、低对比度眩光视力（LCGA）、非侵入性泪膜破裂时间（NIBUT）和脂质层等级（LLG）。在第14天，还评估了相对于基线的主观舒适度，以及对隐形眼镜表面脂质沉积的荧光分光光度评估。
治疗眼和对照眼在基线期时所有测量结果均无差异。治疗眼在第14天时脂质层厚度和泪膜稳定性增加（所有p<0.05），而对照眼则无变化（所有p>0.05）。与对照眼相比，更多比例的参与者报告治疗眼的舒适度有所改善（p=0.002）。在第14天，治疗眼和对照眼在视力或隐形眼镜表面脂质沉积方面没有显著差异（所有p>0.05）。
磷脂脂质体喷雾剂可提高硅水凝胶隐形眼镜佩戴者的泪膜稳定性、脂质层厚度和主观舒适度，且不会对视力或隐形眼镜表面脂质沉积产生不利影响。
