Morgan-Followell Bethanie, Aylward Shawn C
1 Department of Neurology, Nationwide Children's Hospital, Columbus, OH, USA.
J Child Neurol. 2017 Mar;32(4):366-370. doi: 10.1177/0883073816681936. Epub 2016 Dec 8.
The authors aimed to compare the opening pressures of children with demyelinating disease to children with primary intracranial hypertension. Medical records were reviewed for a primary diagnosis of demyelinating disease, or primary intracranial hypertension. Diagnosis of demyelinating disease was made according to either the 2007 or 2012 International Pediatric Multiple Sclerosis Study Group criteria. Primary intracranial hypertension diagnosis was confirmed by presence of elevated opening pressure, normal cerebrospinal fluid composition and neuroimaging. The authors compared 14 children with demyelinating disease to children with primary intracranial hypertension in 1:1 and 1:2 fashions. There was a statistically significant higher BMI in the primary intracranial hypertension group compared to the demyelinating group ( P = .0203). The mean cerebrospinal fluid white blood cell count was higher in the demyelinating disease group compared to primary intracranial hypertension ( P = .0002). Among both comparisons, the cerebrospinal fluid opening pressure, glucose, protein and red blood cell counts in children with demyelinating disease were comparable to age- and sex-matched controls with primary intracranial hypertension.
作者旨在比较患有脱髓鞘疾病的儿童与原发性颅内高压儿童的初压。回顾了有关脱髓鞘疾病或原发性颅内高压的初步诊断的病历。脱髓鞘疾病的诊断依据2007年或2012年国际小儿多发性硬化症研究组标准。原发性颅内高压的诊断通过初压升高、脑脊液成分正常和神经影像学检查来确认。作者以1:1和1:2的方式将14名患有脱髓鞘疾病的儿童与原发性颅内高压儿童进行了比较。与脱髓鞘组相比，原发性颅内高压组的BMI在统计学上显著更高（P = 0.0203）。与原发性颅内高压相比，脱髓鞘疾病组的脑脊液白细胞平均计数更高（P = 0.0002）。在这两种比较中，患有脱髓鞘疾病的儿童的脑脊液初压、葡萄糖、蛋白质和红细胞计数与年龄和性别匹配的原发性颅内高压对照组相当。
