Srb V
Cas Lek Cesk. 1989 Aug 18;128(34):1057-64.
The aim of the International Agency for Research on Cancer (IARC) attached to WHO is to facilitate world-wide cooperation in cancer research in the fields of science, methodology, information service, organization or even legislation. For this purpose the IARC publishes specialized monographs containing critical evaluation of risk materials, their mixtures as well as assessment of working procedures involving the risk of carcinogenesis. Within the IARC scope, so far 700 agents have been submitted for comprehensive investigation from the genotoxic aspect, and 628 out of these yielded valid results; 50 agents listed in Group 1 of demonstrable carcinogens, Group 2 contained 196 agents suspect of various degrees of carcinogenicity (subgroups 2A and 2B). The author compares the internationally accepted list of high-risk agents with the present Czechoslovak list--Guidelines No. 64/1984 containing 15 demonstrable carcinogenic agents and 17 potential carcinogenic agents, and he recommends that the prospective Amendment to the Guidelines No. 64/1984 should respond more keenly to the IARC conclusions and recommendations.
世界卫生组织下属的国际癌症研究机构（IARC）的目标是促进癌症研究在科学、方法、信息服务、组织乃至立法等领域的全球合作。为此，IARC出版专门的专著，其中包含对风险物质、其混合物以及涉及致癌风险的工作程序的批判性评估。在IARC的范围内，到目前为止，已从遗传毒性方面提交了700种物质进行全面调查，其中628种得出了有效结果；在第1组可证实致癌物中有50种物质，第2组包含196种具有不同程度致癌嫌疑的物质（2A和2B亚组）。作者将国际公认的高风险物质清单与目前捷克斯洛伐克的清单——第64/1984号指南（其中包含15种可证实的致癌物质和17种潜在致癌物质）进行了比较，并建议对第64/1984号指南的预期修订应更敏锐地回应IARC的结论和建议。
