Althouse R, Huff J, Tomatis L, Wilbourn J
IARC Monogr Eval Carcinog Risk Chem Hum Suppl. 1979 Sep(1):1-71.
An international ad hoc Working Group of experts in cancer research met at the International Agency for Research on Cancer (IARC) in January 1979 to evaluate the data on human and experimental animal carcinogenicity for 54 chemicals, groups of chemicals, and industrial processes. Monographs for these chemicals were published in Volumes 1-20 of the IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. On the basis of evidence from human studies, 18 of the 54 chemicals and industrial processes are human carcinogens. A further 18 chemicals are probably carcinogenic for humans, although the data were considered not adequate to establish a causal association. To reflect differing degrees of evidence of carcinogenicity within this group, it was further subdivided; for six chemicals there was a high degree of evidence, and for 12 there was a lower degree. Data on the remaining 18 chemicals were considered insufficient to allow any evaluation of carcinogenicity. The report summarizes the background, purpose, and overall conclusions of the Working Group. The evidence supporting the evaluations is given in the Appendix. This volume includes a cumulative index of chemicals for Volumes 1-20 of the IARC Monographs, as well as an index by possible target organ in humans. A condensed version of this report will appear in the December 1979 issue of Cancer Research.
1979年1月，一个国际癌症研究特设专家工作组在国际癌症研究机构（IARC）召开会议，评估了54种化学物质、化学物质组和工业过程的人类致癌性及实验动物致癌性数据。这些化学物质的专论发表在《IARC人类化学物质致癌风险评估专论》第1 - 20卷中。根据人体研究证据，54种化学物质和工业过程中有18种是人类致癌物。另有18种化学物质可能对人类致癌，尽管数据被认为不足以确立因果关联。为反映该组内致癌性证据的不同程度，该组进一步细分；6种化学物质有高度证据，12种有较低程度证据。其余18种化学物质的数据被认为不足以进行致癌性评估。本报告总结了工作组的背景、目的和总体结论。支持评估的证据见附录。本卷包括《IARC专论》第1 - 20卷化学物质累积索引以及按人类可能靶器官分类的索引。本报告的简版将发表在1979年12月的《癌症研究》杂志上。
