Gomi S, Gotoh F, Komatsumoto S, Ishikawa Y, Araki N, Hamada J
Department of Neurology, School of Medicine, Keio University, Tokyo, Japan.
Cephalalgia. 1989 Sep;9(3):179-85. doi: 10.1046/j.1468-2982.1989.0903179.x.
Sweating function and retinal arterial reactivity in patients with migraine were examined during headache-free intervals. The sweat glands were stimulated by intradermal injection of pilocarpine hydrochloride, and molds of sweat droplets were obtained using Silastic. The number of droplets in classic migraine was significantly lower than that in the controls. The retinal arterial response to changes in perfusion pressure was measured by means of a fundus camera. The retinal vasomotor index (-change in retinal arterial diameter (%)/change in effective MABP (mmHg)) was significantly lower in classic and in common migraine than in controls. The above results suggest that sweating function and retinal arterial reactivity are impaired in patients with migraine and that the impairment may play an important role in the pathophysiology of migraine attacks.
在无头痛发作间期对偏头痛患者的出汗功能和视网膜动脉反应性进行了检查。通过皮内注射盐酸毛果芸香碱刺激汗腺，并使用硅橡胶获取汗滴模型。典型偏头痛患者的汗滴数量显著低于对照组。通过眼底照相机测量视网膜动脉对灌注压变化的反应。典型偏头痛和普通偏头痛患者的视网膜血管运动指数（视网膜动脉直径变化率（%）/有效平均动脉压变化率（mmHg））显著低于对照组。上述结果表明，偏头痛患者的出汗功能和视网膜动脉反应性受损，且这种损害可能在偏头痛发作的病理生理学中起重要作用。
