Liu Pei, Zhu Yisi, Lee Seung Hee, Yun Minhee
Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Department of Materials Science and Engineering, The college of engineering, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
Biomed Microdevices. 2016 Dec;18(6):113. doi: 10.1007/s10544-016-0142-3.
In this work, we report a flexible field-effect-transistor (FET) biosensor design based on two-dimensional (2-D) polyaniline (PANI) nanostructure. The flexible biosensor devices were fabricated through a facile and inexpensive method that combines top-down and bottom-up processes. The chemically synthesized PANI nanostructure showed excellent p-type semiconductor properties as well as good compatibility with flexible design. With the 2-D PANI nanostructure being as thin as 80 nm and its extremely large surface-area-to-volume (SA/V) ratio due to the intrinsic properties of PANI chemical synthesis, the developed flexible biosensor exhibited outstanding sensing performance in detecting B-type natriuretic peptide (BNP) biomarkers, and was able to achieve high specificity (averagely 112 folds) with the limit of detection as low as 100 pg/mL. PANI nanostructure under bending condition was also investigated and showed controllable conductance changes being less than 20% with good restorability which may open up the possibility for wearable applications.
在这项工作中，我们报道了一种基于二维（2-D）聚苯胺（PANI）纳米结构的柔性场效应晶体管（FET）生物传感器设计。柔性生物传感器器件通过一种简便且廉价的方法制造，该方法结合了自上而下和自下而上的工艺。化学合成的PANI纳米结构表现出优异的p型半导体特性以及与柔性设计的良好兼容性。由于PANI化学合成的固有特性，二维PANI纳米结构薄至80纳米且具有极大的表面积与体积比（SA/V），所开发的柔性生物传感器在检测B型利钠肽（BNP）生物标志物方面表现出出色的传感性能，并且能够实现高特异性（平均112倍），检测限低至100 pg/mL。还研究了弯曲条件下的PANI纳米结构，其显示出可控的电导变化小于20%且具有良好的恢复性，这可能为可穿戴应用开辟可能性。
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