血红素加氧酶简史：兴衰与复兴
A short history of heme dioxygenases: rise, fall and rise again.
作者信息
Raven Emma L
机构信息
Department of Chemistry, University of Leicester, University Road, Leicester, LE1 7RH, UK.
出版信息
J Biol Inorg Chem. 2017 Apr;22(2-3):175-183. doi: 10.1007/s00775-016-1412-5. Epub 2016 Dec 1.
Abstract
It is well established that there are two different classes of enzymes-tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)-that catalyse the O-dependent oxidation of L-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.
摘要
众所周知，有两类不同的酶——色氨酸2,3-双加氧酶（TDO）和吲哚胺2,3-双加氧酶（IDO）——可催化L-色氨酸依赖氧氧化为N-甲酰犬尿氨酸。但情况并非一直如此。本文简要回顾了早期TDO和IDO文献的历史、参与其中的人员以及这为未来留下的遗产。
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