通过 1,2-重排和 S Ar 氧环化反应的立体控制全合成（-）-鱼藤酮和（-）-达帕诺尔。
Stereocontrolled Total Syntheses of (-)-Rotenone and (-)-Dalpanol by 1,2-Rearrangement and S Ar Oxycyclizations.
机构信息
Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo, 152-8551, Japan.
出版信息
Angew Chem Int Ed Engl. 2017 Jan 2;56(1):182-187. doi: 10.1002/anie.201609253. Epub 2016 Dec 2.
PMID:27910179
Abstract
The total syntheses of (-)-rotenone and (-)-dalpanol have been achieved by a group-selective, stereospecific 1,2-shift of an epoxy alcohol and S Ar cyclizations. Three oxacycles are constructed, thus illustrating a versatile synthetic route to various rotenoids.
摘要
（-）-鱼藤酮和（-）-达帕醇的全合成是通过环氧醇的基团选择性、立体特异性 1,2-迁移和 S Ar 环化来实现的。构建了三个氧杂环，从而展示了一种通用的合成各种鱼藤酮类化合物的方法。
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