Gosavi Manasi, Kumar Lalit, Ratnakar Ashwini, Bannur Hema
Department of Pathology, KLE University's Jawaharlal Nehru Medical College, Nehru Nagar, Belagavi, Karnataka, India.
Pathol Res Pract. 2017 Feb;213(2):170-175. doi: 10.1016/j.prp.2016.10.009. Epub 2016 Oct 26.
Congenital High Airway Obstruction Syndrome (CHAOS) is a rare anomaly where a partial or complete obstruction of upper airway is seen. As a consequence, the foetus develops enlarged lungs, inverted or flattened diaphragm and ascites. The pathological findings in a case of CHAOS is presented.
A 28-year-old primigravida presented with a history of 5 months of amenorrhoea. Ultrasonography revealed enlarged echogenic lungs, cardiac mid-position, inverted diaphragm, foetal ascites and talipes of left foot. The parents opted for termination of pregnancy. Foetal autopsy revealed a male foetus with ascites and talipes of left foot. Lungs were massively enlarged, diaphragm was flattened. A dome-shaped cricoid cartilage at the subglottic level was seen as the cause of obstruction.
CHAOS is a rare anomaly. A foetal autopsy can be helpful in establishing the level and nature of the obstruction and in documenting other associated foetal anomalies.
先天性高气道梗阻综合征（CHAOS）是一种罕见的异常情况，表现为上气道部分或完全梗阻。因此，胎儿会出现肺部增大、膈肌倒置或扁平以及腹水。本文介绍了一例CHAOS病例的病理检查结果。
一名28岁初产妇，有5个月闭经史。超声检查显示肺部回声增强且增大、心脏位于中位、膈肌倒置、胎儿腹水以及左足畸形。父母选择终止妊娠。胎儿尸检显示为一名男性胎儿，有腹水和左足畸形。肺部明显增大，膈肌扁平。声门下水平可见一个圆顶状环状软骨，这是梗阻的原因。
CHAOS是一种罕见的异常情况。胎儿尸检有助于确定梗阻的部位和性质，并记录其他相关的胎儿异常情况。
