Rameshrad Maryam, Razavi Bibi Marjan, Hosseinzadeh Hossein
Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Targeted Drug Delivery Research Center, Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Food Chem Toxicol. 2017 Feb;100:115-137. doi: 10.1016/j.fct.2016.11.035. Epub 2016 Dec 1.
Toxins are natural or chemical poisonous substances with severe side effects on health. Humans are generally exposed by widespread toxic contaminations via air, soil, water, food, fruits and vegetables. Determining a critical antidote agent with extensive effects on different toxins is an ultimate goal for all toxicologists. Traditional medicine is currently perceived as a safe and natural approach against toxins. In this regard, we focused on the protective effects of green tea (Camellia sinensis) and its main components such as catechin, epicatechin, epicatechin gallate, gallocatechin, epigallocatechin and epigallocatechin gallate as a principal source of antioxidants against both natural and chemical toxins. This literate review demonstrates that protective effects of green tea and its constituents were mainly attributed to their anti-oxidative, radical scavenging, chelating, anti-apoptotic properties and modulating inflammatory responses. Although, some studies reveal they have protective effects by increasing toxin metabolism and neutralizing PLA, proteases, hyaluronidase and l-amino acid oxidase enzymes.
毒素是对健康有严重副作用的天然或化学有毒物质。人类通常通过空气、土壤、水、食物、水果和蔬菜中的广泛有毒污染而接触到毒素。确定一种对不同毒素有广泛作用的关键解毒剂是所有毒理学家的最终目标。传统医学目前被视为一种对抗毒素的安全且天然的方法。在这方面，我们重点关注了绿茶（茶树）及其主要成分如儿茶素、表儿茶素、表儿茶素没食子酸酯、没食子儿茶素、表没食子儿茶素和表没食子儿茶素没食子酸酯作为抗氧化剂的主要来源对天然和化学毒素的保护作用。这篇文献综述表明，绿茶及其成分的保护作用主要归因于它们的抗氧化、自由基清除、螯合、抗凋亡特性以及调节炎症反应。尽管一些研究表明它们通过增加毒素代谢以及中和磷脂酶A、蛋白酶、透明质酸酶和L - 氨基酸氧化酶而具有保护作用。
