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Stem Cell Therapy for Perianal Fistulas in Crohn's Disease.

作者信息

Panes Julian

机构信息

Chief of the Gastroenterology Department Chief of the Inflammatory Bowel Diseases Unit Hospital Clinic Barcelona Associate Professor of Medicine University of Barcelona Barcelona, Spain.

出版信息

Gastroenterol Hepatol (N Y). 2016 Oct;12(10):637-640.

PMID:27917079
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5114507/
Abstract
摘要

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1
Stem Cell Therapy for Perianal Fistulas in Crohn's Disease.克罗恩病肛周瘘管的干细胞治疗
Gastroenterol Hepatol (N Y). 2016 Oct;12(10):637-640.
2
Perianal Crohn's disease.肛周克罗恩病
Neth J Med. 1994 Aug;45(2):72-5.
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Treatment of complex perianal fistulas with seton and infliximab in adolescents with Crohn's disease.用挂线疗法和英夫利昔单抗治疗青少年克罗恩病复杂肛周瘘管
J Crohns Colitis. 2014 Aug;8(8):756-62. doi: 10.1016/j.crohns.2014.01.001. Epub 2014 Jan 18.
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Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.异体扩增脂肪间充质干细胞（Cx601）治疗克罗恩病复杂性肛周瘘：一项 3 期随机、双盲对照临床试验。
Lancet. 2016 Sep 24;388(10051):1281-90. doi: 10.1016/S0140-6736(16)31203-X. Epub 2016 Jul 29.
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Perianal Fistulas in Patients With Crohn's Disease, Part 1: Current Medical Management.克罗恩病患者的肛周瘘管，第1部分：当前的药物治疗
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Long-term Evaluation of Allogeneic Bone Marrow-derived Mesenchymal Stromal Cell Therapy for Crohn's Disease Perianal Fistulas.异体骨髓间充质基质细胞治疗克罗恩病肛周瘘的长期评价。
J Crohns Colitis. 2020 Jan 1;14(1):64-70. doi: 10.1093/ecco-jcc/jjz116.
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Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease.干细胞治疗（Cx601）对克罗恩病合并复杂性肛旁瘘患者的长期疗效和安全性。
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Perianal Fistulas in Patients With Crohn's Disease, Part 2: Surgical, Endoscopic, and Future Therapies.克罗恩病患者的肛周瘘管，第2部分：手术、内镜及未来治疗方法
Gastroenterol Hepatol (N Y). 2018 Sep;14(9):521-528.
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Medical Therapy of Perianal Crohn's Disease.肛周克罗恩病的药物治疗
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Perianal fistulas in Crohn's disease: MRI diagnosis and surgical planning: MRI in fistulazing perianal Crohn's disease.克罗恩病中的肛周瘘管：MRI诊断与手术规划：肛周克罗恩病瘘管形成的MRI表现
Abdom Imaging. 2007 Nov;32(6):705-18. doi: 10.1007/s00261-007-9188-2. Epub 2007 Mar 3.

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Polymers (Basel). 2018 Feb 13;10(2):184. doi: 10.3390/polym10020184.
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Stem cells for luminal, fistulizing, and perianal inflammatory bowel disease: a comprehensive updated review of the literature.用于治疗腔道型、瘘管型和肛周炎症性肠病的干细胞：文献的全面更新综述
Stem Cells Cloning. 2018 Nov 27;11:95-113. doi: 10.2147/SCCAA.S135414. eCollection 2018.
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One more chance of fistula healing in inflammatory bowel disease: Stem cell therapy.炎症性肠病中瘘管愈合的又一次机会：干细胞疗法。
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Pathogenesis and persistence of cryptoglandular anal fistula: a systematic review.肛隐窝型肛门瘘管的发病机制和持续存在：系统综述。
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本文引用的文献

1
Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.异体扩增脂肪间充质干细胞（Cx601）治疗克罗恩病复杂性肛周瘘：一项 3 期随机、双盲对照临床试验。
Lancet. 2016 Sep 24;388(10051):1281-90. doi: 10.1016/S0140-6736(16)31203-X. Epub 2016 Jul 29.
2
Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.同种异体骨髓源间充质基质细胞促进克罗恩病患者难治性肛周瘘的愈合。
Gastroenterology. 2015 Oct;149(4):918-27.e6. doi: 10.1053/j.gastro.2015.06.014. Epub 2015 Jun 25.
3
A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease.全球共识：肛门周围瘘管型克罗恩病的分类、诊断和多学科治疗。
Gut. 2014 Sep;63(9):1381-92. doi: 10.1136/gutjnl-2013-306709. Epub 2014 Jun 20.
4
Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease.自体骨髓源性间充质基质细胞治疗瘘管性克罗恩病。
Gut. 2011 Jun;60(6):788-98. doi: 10.1136/gut.2010.214841. Epub 2011 Jan 21.
5
Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial.用于治疗复杂性肛瘘的扩增脂肪源性干细胞：一项II期临床试验。
Dis Colon Rectum. 2009 Jan;52(1):79-86. doi: 10.1007/DCR.0b013e3181973487.
6
Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis.硫唑嘌呤和6-巯基嘌呤用于克罗恩病的荟萃分析
Ann Intern Med. 1995 Jul 15;123(2):132-42. doi: 10.7326/0003-4819-123-2-199507150-00009.