Miyazaki Tatsuya, Sakai Makoto, Sohda Makoto, Tanaka Naritaka, Yokobori Takehiko, Motegi Yoko, Nakajima Masanobu, Fukuchi Minoru, Kato Hiroyuki, Kuwano Hiroyuki
Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan
Department of General Surgical Science, Gunma University Graduate School of Medicine, Gunma University, Gunma, Japan.
Anticancer Res. 2016 Dec;36(12):6557-6562. doi: 10.21873/anticanres.11259.
We evaluated the following preoperative prognostic factors in patients who underwent esophagectomy for esophageal cancer: C-Reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), serum albumin, prognostic nutritional index (PNI), and body mass index (BMI).
This retrospective study included 173 men and 19 women with a mean age of 65.8 years (range=42-86 years) who were scheduled to undergo esophagectomy for esophageal cancer. The association of CRP, NLR, albumin, PNI, and BMI with various clinicopathological factors and prognosis were evaluated.
Univariate analysis revealed that male sex, depth of invasion, nodal metastasis, pStage, high CRP, low PNI, high NLR, and low BMI were significant risk factors for a poor prognosis. Multivariate analysis identified depth of invasion, pStage, and BMI as significant prognostic factors in the Cox proportional hazard model.
The preoperative nutritional status affected the postoperative survival time in patients with esophageal cancer. In particular, a low BMI was an independent prognostic factor for poorer survival in the multivariate analysis.
我们评估了接受食管癌切除术患者的以下术前预后因素：C反应蛋白（CRP）、中性粒细胞与淋巴细胞比值（NLR）、血清白蛋白、预后营养指数（PNI）和体重指数（BMI）。
这项回顾性研究纳入了173名男性和19名女性，平均年龄65.8岁（范围=42-86岁），他们计划接受食管癌切除术。评估了CRP、NLR、白蛋白、PNI和BMI与各种临床病理因素及预后的相关性。
单因素分析显示，男性、浸润深度、淋巴结转移、p分期、高CRP、低PNI、高NLR和低BMI是预后不良的显著危险因素。多因素分析确定浸润深度、p分期和BMI是Cox比例风险模型中的显著预后因素。
术前营养状况影响食管癌患者术后生存时间。特别是，低BMI在多因素分析中是生存较差的独立预后因素。
