Gasque Philippe, Bandjee Marie Christine Jaffar, Reyes Marcela Mercado, Viasus Diego
UMR PIMIT, Processus Infectieux en Milieu Insulaire Tropical Université de La Réunion, INSERM U1187, CNRS 9192, IRD 249, St. Denis, France.
National Health Institute, Public Health Research Division, Bogotá.
J Infect Dis. 2016 Dec 15;214(suppl 5):S446-S448. doi: 10.1093/infdis/jiw362.
Chikungunya alphavirus has caused large epidemics worldwide and leads to acute incapacitating polyarthralgia. The inflammatory reaction over several days will drive robust innate and humoral responses essential to control the infection. Critically, fatal cases and mother-to-child transmission have also been described. Chikungunya can give rise to chronic musculoskeletal diseases, which can last for months to years, particularly in elderly individuals, and occasionally leads to seronegative rheumatoid arthritis-like pathologies. Histopathological studies of patient biopsy specimens and animal models have revealed that chikungunya virus can hide in tissue sanctuaries, and ongoing research should help to decipher the inflammatory mechanisms of tissue injuries.
基孔肯雅甲病毒已在全球范围内引发大规模疫情，并导致急性致残性多关节痛。数天内的炎症反应将引发强大的固有免疫和体液免疫反应，这对于控制感染至关重要。关键的是，也有致命病例和母婴传播的报道。基孔肯雅病毒可引发慢性肌肉骨骼疾病，这种疾病可持续数月至数年，在老年人中尤为常见，偶尔还会导致血清阴性类风湿关节炎样病变。对患者活检标本和动物模型的组织病理学研究表明，基孔肯雅病毒可隐匿于组织庇护所中，正在进行的研究应有助于阐明组织损伤的炎症机制。
