洛西肽胺（CR - 1505）对人体基础状态及蛙皮素刺激下胆囊容积的影响。
The effect of loxiglumide (CR-1505) on basal and bombesin-stimulated gallbladder volume in man.
作者信息
Douglas B R, Jebbink M C, Tjon a Tham R T, Jansen J B, Lamers C B
机构信息
Department of Gastroenterology-Hepatology, University Hospital, Leiden, The Netherlands.
出版信息
Eur J Pharmacol. 1989 Jul 18;166(2):307-9. doi: 10.1016/0014-2999(89)90073-3.
This study was undertaken in 5 normal subjects to determine the role of cholecystokinin (CCK) in the regulation of basal gallbladder volume and gallbladder contraction stimulated by infusion of bombesin. Administration of the CCK-receptor antagonist, loxiglumide (CR-1505), led to doubling of the gallbladder volume (increase 104 +/- 26%; P less than 0.05) and reduced the bombesin-stimulated gallbladder contraction from 69 +/- 17 to 19 +/- 17% (P less than 0.05). The findings provide evidence suggesting that CCK plays an important role in the regulation of basal gallbladder tone and in mediating the gallbladder contraction induced by the administration of bombesin.
本研究对5名正常受试者进行，以确定胆囊收缩素（CCK）在调节基础胆囊容积以及由蛙皮素输注刺激引起的胆囊收缩中的作用。给予CCK受体拮抗剂洛谷酰胺（CR - 1505）导致胆囊容积加倍（增加104±26%；P<0.05），并使蛙皮素刺激的胆囊收缩从69±17%降至19±17%（P<0.05）。这些发现提供了证据，表明CCK在调节基础胆囊张力以及介导蛙皮素给药引起的胆囊收缩中起重要作用。
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