Aftab Raja Ahsan, Khan Amer Hayat, Adnan Azreen Syazril, Sulaiman Syed Azhar Syed, Khan Tahir Mehmood
Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences Universiti Sains Malaysia, 11800 Penang, Malaysia.
CKD Resource Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia.
Sci Rep. 2016 Dec 6;6:36592. doi: 10.1038/srep36592.
To assess the effectiveness of losartan 50 mg on post dialysis euvolemic hypertensive patients against standard antihypertensive pharmacotherapy. A multicentre, prospective, randomized, single-blind trial was conducted to assess the effect of losartan 50 mg every other day (EOD), once a morning (OM) among post-dialysis euvolemic hypertensive patients. Covariate-adaptive randomization was used to allocate participants to a standard or treatment arm, and they were followed up for eight weeks. Pre-, intra- and post-dialysis session blood pressure (BP) measurements were recorded along with any adverse events. A total of 88 patients were randomized into standard (n = 44) and treatment arms (n = 44) and were followed for a period of 8 weeks. In the standard group, the mean post-dialysis blood pressure dropped by 0.3 mmHg by the end of the 8 week. However the treatment arm reported a drop of 2.4 mmHg of BP drop during the 8-week trial period. Analysis suggests that there was a significant difference in blood pressure readings at the end of 8 weeks among patients treated with losartan (P < 0.001). However, no such statistical association was observed in the standard arm (P 0.75). A slow, steady significant decline in post-dialysis BP was observed among euvolemic hypertensive patients that were treated with losartan 50 mg.
评估氯沙坦50毫克对透析后血容量正常的高血压患者相对于标准抗高血压药物治疗的有效性。进行了一项多中心、前瞻性、随机、单盲试验，以评估氯沙坦50毫克隔日一次（EOD）、每天早晨一次（OM）对透析后血容量正常的高血压患者的疗效。采用协变量适应性随机化将参与者分配到标准组或治疗组，并对他们进行了为期八周的随访。记录透析前、透析中和透析后的血压（BP）测量值以及任何不良事件。共有88名患者被随机分为标准组（n = 44）和治疗组（n = 44），并随访了8周。在标准组中，到8周结束时，透析后平均血压下降了0.3 mmHg。然而，治疗组在8周试验期内报告血压下降了2.4 mmHg。分析表明，接受氯沙坦治疗的患者在8周结束时的血压读数存在显著差异（P < 0.001）。然而，在标准组中未观察到这种统计学关联（P = 0.75）。在接受50毫克氯沙坦治疗的血容量正常的高血压患者中，观察到透析后血压缓慢、稳定且显著下降。
