11C-蛋氨酸 PET/CT 提高了年轻复发性多发性骨髓瘤伴不典型髓外表现患者微小残留病灶的检出率。

Improved Detection of Minimal Residual Disease by 11C-Methionine PET/CT in a Young Patient With Unusual Extramedullary Presentation of Recurrent Multiple Myeloma.

机构信息

From the Institutes of *Nuclear Medicine, and †Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.

出版信息

Clin Nucl Med. 2017 Feb;42(2):e130-e134. doi: 10.1097/RLU.0000000000001462.

Abstract

Extramedullary relapse of multiple myeloma (MM) is uncommon. A 40-year-old woman with history of MM underwent PET/CT using C-methionine (C-MET) after the detection of a vulvar lesion on MRI, biopsy proven to be extramedullary relapse of MM. The vulvar lesion was negative at the F-FDG PET/CT but showed high uptake of C-MET; focal uptake of both F-FDG and C-MET was shown within the muscles of the left leg, histologically confirmed as extramedullary relapse of MM. F-FDG PET/CT performed after chemotherapy showed no uptake in both sites, whereas posttreatment C-MET PET/CT showed persistence of residual uptake within the vulvar lesion.

摘要

骨髓外多发性骨髓瘤（MM）复发并不常见。一位 40 岁的女性患者，曾患有 MM，在 MRI 检测到外阴病变后，进行了 C-蛋氨酸（C-MET）PET/CT 检查，活检证实为骨髓外 MM 复发。外阴病变在 F-FDG PET/CT 上为阴性，但 C-MET 摄取较高；左腿肌肉内显示出 F-FDG 和 C-MET 的摄取均为局限性，经组织学检查证实为骨髓外 MM 复发。化疗后行 F-FDG PET/CT 检查，两处均未见摄取，而治疗后 C-MET PET/CT 显示外阴病变内仍有残留摄取。