From the Institutes of *Nuclear Medicine, and †Hematology, Università Cattolica del Sacro Cuore, Rome, Italy.
Clin Nucl Med. 2017 Feb;42(2):e130-e134. doi: 10.1097/RLU.0000000000001462.
Extramedullary relapse of multiple myeloma (MM) is uncommon. A 40-year-old woman with history of MM underwent PET/CT using C-methionine (C-MET) after the detection of a vulvar lesion on MRI, biopsy proven to be extramedullary relapse of MM. The vulvar lesion was negative at the F-FDG PET/CT but showed high uptake of C-MET; focal uptake of both F-FDG and C-MET was shown within the muscles of the left leg, histologically confirmed as extramedullary relapse of MM. F-FDG PET/CT performed after chemotherapy showed no uptake in both sites, whereas posttreatment C-MET PET/CT showed persistence of residual uptake within the vulvar lesion.
骨髓外多发性骨髓瘤（MM）复发并不常见。一位 40 岁的女性患者，曾患有 MM，在 MRI 检测到外阴病变后，进行了 C-蛋氨酸（C-MET）PET/CT 检查，活检证实为骨髓外 MM 复发。外阴病变在 F-FDG PET/CT 上为阴性，但 C-MET 摄取较高；左腿肌肉内显示出 F-FDG 和 C-MET 的摄取均为局限性，经组织学检查证实为骨髓外 MM 复发。化疗后行 F-FDG PET/CT 检查，两处均未见摄取，而治疗后 C-MET PET/CT 显示外阴病变内仍有残留摄取。
