Hegerl U, Ulke C
Research Center of the German Depression Foundation, Leipzig, Germany; University of Leipzig, Leipzig, Germany.
Research Center of the German Depression Foundation, Leipzig, Germany.
Prog Brain Res. 2016;229:239-254. doi: 10.1016/bs.pbr.2016.06.001. Epub 2016 Jul 7.
Fatigue is considered to be an important and frequent factor in motivation problems. However, this term lacks clinical and pathophysiological validity. Semantic precision has to be improved. Lack of drive and tiredness with increased sleepiness as observed in fatigue in the context of inflammatory and immunological processes (hypoaroused fatigue) has to be separated from inhibition of drive and tiredness with prolonged sleep onset latency as observed in major depression (hyperaroused fatigue). Subjective experiences as reported by patients, as well as clinical, behavioral, and neurobiological findings support the validity and importance of this distinction. A practical clinical procedure for how to separate hypo- from hyperaroused fatigue will be proposed.
疲劳被认为是导致动机问题的一个重要且常见的因素。然而，这个术语缺乏临床和病理生理学上的有效性。语义精确性有待提高。在炎症和免疫过程中的疲劳（低唤醒疲劳）中观察到的动力缺乏和困倦增加伴疲劳感，必须与在重度抑郁症中观察到的动力抑制和困倦伴入睡潜伏期延长的疲劳（高唤醒疲劳）区分开来。患者报告的主观体验以及临床、行为和神经生物学发现都支持这种区分的有效性和重要性。本文将提出一种区分低唤醒疲劳和高唤醒疲劳的实用临床方法。
