与慢性炎症性脱髓鞘性多发性神经病相关的眼部神经肌强直
Ocular Neuromyotonia Associated with Chronic Inflammatory Demyelinating Polyneuropathy.
作者信息
Kung Nathan H, Bucelli Robert C, McClelland Collin M, Van Stavern Gregory P
机构信息
Department of Neurology, Washington University in St. Louis , St. Louis, Missouri, USA.
Department of Ophthalmology and Visual Sciences, Washington University in St. Louis , St. Louis, Missouri, USA.
出版信息
Neuroophthalmology. 2015 Aug 24;39(5):240-242. doi: 10.3109/01658107.2015.1059464. eCollection 2015 Oct.
Ocular neuromyotonia (ONM) is a neuro-ophthalmic disorder characterized by episodic diplopia caused by contraction of one or more ocular muscles due to spontaneous excitation of the respective ocular motor nerve. We report a patient whose ocular neuromyotonia arose in the setting of a subacute demyelinating polyneuropathy consistent with chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently resolved following the initiation of intravenous immunoglobulin (IVIg) for her neuropathy. Our patient provides additional evidence towards the role of demyelination and ephaptic neurotransmission in ocular neuromyotonia and also represents the first reported case of ocular neuromyotonia associated with a systemic neurological condition.
眼肌神经性肌强直（ONM）是一种神经眼科疾病，其特征为由于相应眼运动神经的自发兴奋，导致一条或多条眼外肌收缩，进而引起发作性复视。我们报告了一例患者，其眼肌神经性肌强直发生在与慢性炎症性脱髓鞘性多发性神经病（CIDP）相符的亚急性脱髓鞘性多发性神经病背景下，随后在开始静脉注射免疫球蛋白（IVIg）治疗其神经病后症状得到缓解。我们的患者为脱髓鞘和触突间神经传递在眼肌神经性肌强直中的作用提供了更多证据，并且也是首例报道的与全身性神经系统疾病相关的眼肌神经性肌强直病例。
Zotero 插件