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[高压氧、丘脑下部药物及其联合应用对实验性小循环血管栓塞所致肺水肿的影响]

[Effects of hyperbaric oxygenation, thalamonal and their combination on pulmonary edema in experimental embolism of blood vessels of the lesser circulation].

作者信息

Kurygin G V, Polikarpov V V, Fafurina M L

出版信息

Grudn Khir. 1989 Jul-Aug(4):36-9.

PMID:2792875
Abstract

Hyperbaric oxygenation leads to 100% survival of albino rats in development of fatal under normobaric conditions pulmonary edema induced by embolism of the vessels of the lesser circulation by olive oil. The degree of lung hydration and the amount of pleural effusion diminish significantly in this case but hyperemia of the pulmonary tissue persists. Thalamonal produces a moderate protective effect in fat embolism, which is manifested by reduced steeping of the lungs in fluid. Under the condition of hyperbaric oxygenation thalamonal fails to change the degree of edema and reduces slightly blood filling of the lungs in fat embolism. Hyperbaric oxygenation, thalamonal and their combination do not protect the lungs from edema and hyperemia in mechanical embolism of the vessels of the lesser circulation by lycopodium.

摘要

在常压条件下,由橄榄油栓塞小循环血管所致的致命性肺水肿形成过程中,高压氧疗可使白化大鼠100%存活。在此情况下,肺组织含水量及胸腔积液量显著减少,但肺组织充血仍持续存在。氯胺酮在脂肪栓塞中产生中度保护作用,表现为肺在液体中的下沉程度降低。在高压氧疗条件下,氯胺酮未能改变脂肪栓塞时的水肿程度,且使肺充血稍有减轻。在由石松子机械栓塞小循环血管时,高压氧疗、氯胺酮及其联合应用均不能保护肺组织免受水肿和充血的影响。

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