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尿脂联素快速检测试纸条对先兆子痫诊断价值的评估:一项前瞻性多中心研究。

Assessment of the diagnostic value of a urinary adipsin rapid strip test for pre-eclampsia: A prospective multicenter study.

作者信息

Peng Bing, Zhang Li, Yan Jianying, Qi Hongbo, Zhang Weiyuan, Fan Ling, Hu Yayi, Lin Li, Li Xiaotian, Hu Rong, Xie Lan, Zhang Jianping, Wu Yanqiao, Li Li, Zhou Rong

机构信息

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Department of Obstetrics and Gynecology, Maternity and Child Care Service Centers in Fujian Province, Fuzhou, China.

出版信息

J Obstet Gynaecol Res. 2017 Jan;43(1):30-33. doi: 10.1111/jog.13156. Epub 2016 Dec 8.

DOI:10.1111/jog.13156
PMID:27928850
Abstract

AIM

The purpose of the present study was to evaluate the clinical value of the rapid strip test of urinary adipsin for the quick diagnosis of pre-eclampsia.

METHODS

In a multicenter diagnostic test study, we studied the diagnostic accuracy of the rapid strip test of urinary adipsin in women presenting with pre-eclampsia. A total of 204 pre-eclampsia patients and 254 healthy pregnant women were recruited for this study, respectively. The rapid strip test of urinary adipsin was used to detect the adipsin in the urine of each patient.

RESULTS

The diagnostic value of the rapid strip test of urinary adipsin for pre-eclampsia was demonstrated by its high sensitivity and specificity (95.10% and 97.64%, respectively). The diagnostic accuracy was 96.51%. The consistency analysis showed that the kappa value was 0.93 compared with the gold standard diagnosis of pre-eclampsia.

CONCLUSION

The rapid strip test of urinary adipsin is a non-invasive test for the diagnosis of pre-eclampsia with high sensitivity and specificity. It could help the quick diagnosis of pre-eclampsia in clinical practice greatly.

摘要

目的

本研究旨在评估尿脂联素快速检测条对子痫前期快速诊断的临床价值。

方法

在一项多中心诊断试验研究中,我们研究了尿脂联素快速检测条对患有子痫前期女性的诊断准确性。本研究分别招募了204例子痫前期患者和254例健康孕妇。使用尿脂联素快速检测条检测每位患者尿液中的脂联素。

结果

尿脂联素快速检测条对子痫前期的诊断价值体现在其高敏感性和特异性上(分别为95.10%和97.64%)。诊断准确性为96.51%。一致性分析表明,与子痫前期的金标准诊断相比,kappa值为0.93。

结论

尿脂联素快速检测条是一种用于诊断子痫前期的非侵入性检测方法,具有高敏感性和特异性。它可在临床实践中极大地帮助子痫前期的快速诊断。

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