Moslemizadeh N, Yousefnejad K, Moghadam T Galini, Peyvandi S
Department of Obstetric and Gynecology, Imam Khomeini Hospital, Amir-Mazandarani Boulevard, P.O. Box 48166-33131, Sari, Iran.
Pak J Biol Sci. 2008 Nov 15;11(22):2584-8. doi: 10.3923/pjbs.2008.2584.2588.
Mild or severe preeclampsia is responsible for about 70% of hypertensive disorders observed during pregnancy and 24 h urine collection is a gold standard for diagnosis ofpreeclampsia. This study was performed to determine whether the gold standard of 24 h urine protein value in pre-eclampsia can be substituted with 8 or 12 h urine protein values and to evaluate the effect of ambulation and immobilization on amount of protein excretion. A cross sectional study was conducted on 40 women with pre-eclampsia (BP > or = 140/90 mmHg), who referred to the Department of Obstetric and Gynecology, Imam Khomeiny hospital in Sari, Iran from April 2005 to September 2005. Positive urinary strip for protein of at least 1+ samples were collected over 24 h in subsequent periods: the first 8 h and the next 4 h and remaining 12 h urine, in separate containers. The correlation between groups was determined by Pearson's correlation. A total of 40 women were recurited in this study of which 36 had completed urine collection. A total of 21 had mild proteinuria, 5 had severe proteinuria and 10 had no proteinuria. There was significant correlation between the 8 or 12 h (day) and 12 h (night) with 24 h urine protein. Total protein values of 8 and 12 h (day) and 12 h (night) samples, positively correlated with values of 24 h samples in pre-eclampsia and could be substituted for assessment of proteinuria instead of 24 h urine collection in women with pre-eclampsia, as a simpler, faster and cheaper method for diagnosis of pre-eclampsia. And ambulation and immobilization in preeclamptic patients has not any effect on protein excretion.
轻度或重度子痫前期约占孕期观察到的高血压疾病的70%，24小时尿蛋白收集是诊断子痫前期的金标准。本研究旨在确定子痫前期24小时尿蛋白值的金标准是否可以用8小时或12小时尿蛋白值替代，并评估活动和固定对蛋白质排泄量的影响。对2005年4月至2005年9月转诊至伊朗萨里伊玛目霍梅尼医院妇产科的40例子痫前期患者（血压≥140/90 mmHg）进行了一项横断面研究。在随后的时间段内，分别在不同容器中收集24小时内至少1+蛋白样本的阳性尿试纸条：最初8小时、接下来4小时以及剩余12小时的尿液。通过Pearson相关性确定组间相关性。本研究共纳入40名女性，其中36名完成了尿液收集。共有21名有轻度蛋白尿，5名有重度蛋白尿，10名无蛋白尿。8小时或12小时（白天）以及12小时（夜间）与24小时尿蛋白之间存在显著相关性。子痫前期患者8小时和12小时（白天）以及12小时（夜间）样本的总蛋白值与24小时样本的值呈正相关，对于子痫前期女性，可替代24小时尿收集用于评估蛋白尿，作为一种更简单、快速且便宜的子痫前期诊断方法。并且子痫前期患者的活动和固定对蛋白质排泄没有任何影响。
