鉴定出一个 CD133-CD55- 群体，其功能为胎儿共同骨骼祖细胞。

Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.

机构信息

Divison of Hematopoietic Stem Cell and Leukemia Research, Gehr Family Center for Leukemia Research, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA 91010, USA.

出版信息

Sci Rep. 2016 Dec 8;6:38632. doi: 10.1038/srep38632.

DOI:10.1038/srep38632

PMID:27929130

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5144148/

Abstract

In this study, we identified a CD105+CD90.1-CD133-CD55- (CD133-CD55-) population in the fetal skeletal element that can generate bone and bone marrow. Besides osteoblasts and chondrocytes, the CD133-CD55- common progenitors can give rise to marrow reticular stromal cells and perivascular mesenchymal progenitors suggesting they function as the fetal common skeletal progenitor. Suppression of CXCL12 and Kitl expression in CD133-CD55- common progenitors severely disrupted the BM niche formation but not bone generation. Thus, CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow.

摘要

在这项研究中，我们在胎儿骨骼元素中鉴定出一个 CD105+CD90.1-CD133-CD55-（CD133-CD55-）群体，该群体能够生成骨和骨髓。除成骨细胞和成软骨细胞外，CD133-CD55-共同祖细胞还可以产生骨髓网状基质细胞和血管周围间充质祖细胞，提示它们作为胎儿共同骨骼祖细胞发挥功能。在 CD133-CD55-共同祖细胞中抑制 CXCL12 和 Kitl 的表达严重破坏了骨髓龛的形成，但不影响骨生成。因此，CD133-CD55-共同祖细胞是发育中骨髓中产生 CXCL12 和 Kitl 的细胞的主要来源。