钙化性主动脉瓣狭窄的风险因素谱
Risk factor profile of calcific aortic stenosis.
作者信息
Sathyamurthy I, Alex Shaji, Kirubakaran K, Sengottuvelu G, Srinivasan K N
机构信息
Department of Cardiology, Apollo Main Hospital, Chennai, India.
Apollo Main Hospitals, India.
出版信息
Indian Heart J. 2016 Nov-Dec;68(6):828-831. doi: 10.1016/j.ihj.2016.04.007. Epub 2016 Apr 28.
BACKGROUND
Calcific aortic stenosis and coronary artery disease share common risk factors. In some of the previous studies statins have been used to retard the progression of aortic stenosis, but the results were inconsistent.
METHODS
One hundred and ten patients of CAS above the age of 40 years have undergone clinical, biochemical and echocardiographic evaluation. Coronary angiograms were done in 66% of them.
RESULTS
Male to female ratio was 2:1. Patients of CAS with CAD showed higher prevalence of diabetes, hypertension, dyslipidemia, smoking and family history of CAD. Prevalence of obesity and bicuspid aortic valve by echocardiogram was high in those without CAD.
CONCLUSIONS
On comparison of prevalence of risk factor in those with and without associated CAD, there was higher prevalence of diabetes (65% vs 30%), hypertension (52% vs 43%), dyslipidemia (69% vs 52%), smoking (24% vs 18%) and family history of CAD (34% vs 16%) in those with associated CAD. The incidence of obesity was higher in those without CAD (20% vs 30%). The difference observed in diabetes alone was found to be statistically significant.
背景
钙化性主动脉瓣狭窄与冠状动脉疾病有共同的危险因素。在一些先前的研究中，他汀类药物已被用于延缓主动脉瓣狭窄的进展，但结果并不一致。
方法
110例40岁以上的钙化性主动脉瓣狭窄患者接受了临床、生化和超声心动图评估。其中66%的患者进行了冠状动脉造影。
结果
男女比例为2:1。合并冠心病的钙化性主动脉瓣狭窄患者糖尿病、高血压、血脂异常、吸烟及冠心病家族史的患病率更高。无冠心病患者经超声心动图检查发现肥胖和二叶式主动脉瓣的患病率较高。
结论
比较合并冠心病和未合并冠心病患者的危险因素患病率，合并冠心病患者糖尿病（65%对30%）、高血压（52%对43%）、血脂异常（69%对52%）、吸烟（24%对18%）及冠心病家族史（34%对16%）的患病率更高。无冠心病患者肥胖的发生率更高（20%对30%）。仅糖尿病方面观察到的差异具有统计学意义。
Zotero 插件