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Low-Density Lipoprotein Cholesterol, Type 2 Diabetes and Progression of Aortic Stenosis: The RED-CARPET Heart Valve Subgroup Cohort Study.低密度脂蛋白胆固醇、2型糖尿病与主动脉瓣狭窄进展：红毯心脏瓣膜亚组队列研究
Rev Cardiovasc Med. 2024 Aug 7;25(8):276. doi: 10.31083/j.rcm2508276. eCollection 2024 Aug.
2
Unraveling the Enigma of Moderate Aortic Stenosis: Challenges and Future Prospects.揭开中度主动脉瓣狭窄之谜：挑战与未来前景
J Clin Med. 2024 Jun 14;13(12):3478. doi: 10.3390/jcm13123478.
3
Lp(a) in the Pathogenesis of Aortic Stenosis and Approach to Therapy with Antisense Oligonucleotides or Short Interfering RNA.脂蛋白(a)在主动脉瓣狭窄发病机制中的作用及反义寡核苷酸或短干扰 RNA 治疗方法。
Int J Mol Sci. 2023 Oct 6;24(19):14939. doi: 10.3390/ijms241914939.
4
Single Ascending Dose Study of a Short Interfering RNA Targeting Lipoprotein(a) Production in Individuals With Elevated Plasma Lipoprotein(a) Levels.脂蛋白(a)生产的短干扰 RNA 靶向的单次递增剂量研究在个体血浆脂蛋白(a)水平升高。
JAMA. 2022 May 3;327(17):1679-1687. doi: 10.1001/jama.2022.5050.
5
Is Asymptomatic Severe Aortic Stenosis Still a Waiting Game?无症状重度主动脉瓣狭窄仍需等待观察吗？
Circulation. 2022 Mar 22;145(12):874-876. doi: 10.1161/CIRCULATIONAHA.121.058598. Epub 2022 Mar 21.
6
Calcified aortic valve disease complicated with and without diabetes mellitus: the underlying pathogenesis.钙化性主动脉瓣疾病伴或不伴糖尿病：潜在发病机制。
Rev Cardiovasc Med. 2022 Jan 11;23(1):7. doi: 10.31083/j.rcm2301007.
7
Decreased Glucagon-Like Peptide-1 Is Associated With Calcific Aortic Valve Disease: GLP-1 Suppresses the Calcification of Aortic Valve Interstitial Cells.胰高血糖素样肽-1降低与钙化性主动脉瓣疾病相关：胰高血糖素样肽-1抑制主动脉瓣间质细胞钙化。
Front Cardiovasc Med. 2021 Aug 26;8:709741. doi: 10.3389/fcvm.2021.709741. eCollection 2021.
8
Association between Aortic Valve Calcification Progression and Coronary Atherosclerotic Plaque Volume Progression in the PARADIGM Registry.PARADIGM 注册研究中主动脉瓣钙化进展与冠状动脉粥样硬化斑块体积进展的相关性。
Radiology. 2021 Jul;300(1):79-86. doi: 10.1148/radiol.2021202630. Epub 2021 May 11.
9
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.2020 ACC/AHA 瓣膜性心脏病患者管理指南：执行摘要：美国心脏病学会/美国心脏协会临床实践指南联合委员会的报告。
J Am Coll Cardiol. 2021 Feb 2;77(4):450-500. doi: 10.1016/j.jacc.2020.11.035. Epub 2020 Dec 17.
10
Chronic High Glucose Concentration Induces Inflammatory and Remodeling Changes in Valvular Endothelial Cells and Valvular Interstitial Cells in a Gelatin Methacrylate 3D Model of the Human Aortic Valve.在明胶甲基丙烯酸酯三维人主动脉瓣模型中，慢性高糖浓度诱导瓣膜内皮细胞和瓣膜间质细胞发生炎症和重塑变化。
Polymers (Basel). 2020 Nov 25;12(12):2786. doi: 10.3390/polym12122786.

Could the Hemodynamic Progression of Aortic Valve Stenosis be Slowed Pharmacologically? The Unsolved Dilemma.

作者信息

Santangelo Gloria, Antonini-Canterin Francesco, Faggiano Pompilio

机构信息

Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, 20122 Milano, Italy.

Department of Cardiology, ORAS Hospital, 31045 Motta di Livenza (Treviso), Italy.

出版信息

Rev Cardiovasc Med. 2025 Feb 12;26(2):26537. doi: 10.31083/RCM26537. eCollection 2025 Feb.

DOI:10.31083/RCM26537
PMID:40026530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11868886/
Abstract
摘要