Wight Thomas N
Matrix Biology Program, Benaroya Research Institute, 1201 9th Avenue, Seattle, WA 98101, United States.
Matrix Biol. 2017 Jul;60-61:38-56. doi: 10.1016/j.matbio.2016.12.001. Epub 2016 Dec 6.
Hyaluronan and versican are extracellular matrix (ECM) components that are enriched in the provisional matrices that form during the early stages of development and disease. These two molecules interact to create pericellular "coats" and "open space" that facilitate cell sorting, proliferation, migration, and survival. Such complexes also impact the recruitment of leukocytes during development and in the early stages of disease. Once thought to be inert components of the ECM that help hold cells together, it is now quite clear that they play important roles in controlling cell phenotype, shaping tissue response to injury and maintaining tissue homeostasis. Conversion of hyaluronan-/versican-enriched provisional matrix to collagen-rich matrix is a "hallmark" of tissue fibrosis. Targeting the hyaluronan and versican content of provisional matrices in a variety of diseases including, cardiovascular disease and cancer, is becoming an attractive strategy for intervention.
透明质酸和多功能蛋白聚糖是细胞外基质（ECM）的组成成分，在发育和疾病早期形成的临时基质中含量丰富。这两种分子相互作用，形成细胞周围的“包膜”和“开放空间”，促进细胞分选、增殖、迁移和存活。此类复合物在发育过程和疾病早期阶段也会影响白细胞的募集。曾经被认为是有助于将细胞聚集在一起的细胞外基质惰性成分，现在很清楚它们在控制细胞表型、塑造组织对损伤的反应以及维持组织稳态方面发挥着重要作用。富含透明质酸和多功能蛋白聚糖的临时基质向富含胶原蛋白的基质转化是组织纤维化的一个“标志”。针对包括心血管疾病和癌症在内的多种疾病中的临时基质的透明质酸和多功能蛋白聚糖含量进行干预，正成为一种有吸引力的策略。
