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一例具有非典型病理表现及化学性脑膜炎的肠源性囊肿

An enterogenous cyst with atypical pathological findings and chemical meningitis.

作者信息

Wang Lu, Chang Xiaona, Fu Chao, Yu Weidong, Fang Xiaoxuan

机构信息

Department of Neurosurgery, The China-Japan Union Hospital, Jilin University, Changchun, 130033 Jilin People's Republic of China.

The Key Laboratory of Pathobiology, Ministry of Education, Bethune Medical School, Jilin University, Changchun, 130021 Jilin People's Republic of China.

出版信息

Springerplus. 2016 Nov 21;5(1):1993. doi: 10.1186/s40064-016-3677-0. eCollection 2016.

Abstract

INTRODUCTION

Intracranial enterogenous cysts are rare and mainly occur in the posterior fossa. These cysts are usually extra-axial, midline, anterior to the brainstem, or at the cerebellopontine angle. We report a case of an enterogenous cyst in which diagnosis was difficult because the lesion showed atypical pathologic findings.

CASE PRESENTATION

A healthy 41-year-old man complained of paroxysmal occipital headaches lasting over a week, with increased severity for 3 days accompanied by slight dizziness and mild nausea. Magnetic resonance imaging showed a cystic lesion between clivus and brainstem. The patient underwent surgery for removal of the lesion via the right-sided far-later approach, and the lesion was resected totally. Although pathologic examinations showed a cyst had a mono-to-multilayered squamous epithelium, which are not accord with typical enterogenous cyst, the diagnosis was finally made based on the presence of basement membrane and immunohistochemical results.

DISCUSSION AND EVALUATION

To confirm the diagnosis of enterogenous cyst, further pathologic examinations were performed and immunohistochemical characters were summarized. Chemical meningitis, a rare complication of enterogenous cyst, happened in current case. Use a syringe and aspirate the contents before incision might be a procedure to prevent chemical meningitis.

CONCLUSIONS

To our knowledge, this is the first report of an enterogenous cyst associated with mono-to-multilayered squamous epithelium. Although during the follow-up time, no recurrence happened, long-term follow-up is needed.

摘要

引言

颅内肠源性囊肿罕见,主要发生于后颅窝。这些囊肿通常位于轴外、中线、脑干前方或桥小脑角。我们报告一例肠源性囊肿病例,该病变显示非典型病理表现,诊断困难。

病例介绍

一名41岁健康男性主诉阵发性枕部头痛持续超过一周,3天来症状加重,伴有轻度头晕和恶心。磁共振成像显示斜坡与脑干之间有一囊性病变。患者通过右侧远外侧入路接受手术切除病变,病变被完全切除。尽管病理检查显示囊肿有单层至多层鳞状上皮,这与典型的肠源性囊肿不符,但最终根据基底膜的存在及免疫组化结果做出诊断。

讨论与评估

为确诊肠源性囊肿,进行了进一步的病理检查并总结了免疫组化特征。本病例发生了肠源性囊肿罕见的并发症——化学性脑膜炎。切开前用注射器抽吸囊内容物可能是预防化学性脑膜炎的一种方法。

结论

据我们所知,这是首例与单层至多层鳞状上皮相关的肠源性囊肿报告。尽管在随访期间未发生复发,但仍需要长期随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7559/5118380/7e7ff01eae07/40064_2016_3677_Fig1_HTML.jpg

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