钴催化的以偶氮二甲酸酯为羰基源的 C(sp)-H 键羰基化反应。
Cobalt-Catalyzed Carbonylation of C(sp)-H Bonds with Azodicarboxylate as the Carbonyl Source.
机构信息
CAS Key Laboratory of Receptor Research, and Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences , Shanghai 201203, China.
University of Chinese Academy of Sciences , Beijing 100049, China.
出版信息
Org Lett. 2016 Nov 18;18(22):5960-5963. doi: 10.1021/acs.orglett.6b03111. Epub 2016 Nov 8.
A novel and efficient approach for the C(sp)-H bond carbonylation of benzamides has been developed using stable and inexpensive Co(OAc)·4HO as the catalyst and the commercially available and easily handling azodicarboxylates as the nontoxic carbonyl source. A broad range of substrates bearing diverse functional groups were tolerated. This is the first example where cobalt-catalyzed C(sp)-H bond carbonylation occurs with azodicarboxylate as the carbonyl source.
一种新颖、高效的酰胺 C(sp)-H 键羰基化方法已经被开发出来，使用稳定且廉价的 Co(OAc)·4HO 作为催化剂，以及商业上可用且易于处理的偶氮二甲酸酯作为无毒羰基源。该方法容忍广泛的带有各种不同官能团的底物。这是首例以偶氮二甲酸酯作为羰基源，钴催化 C(sp)-H 键羰基化反应的例子。
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